Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles

被引：22

作者：

Chandrasekaran, Navin Chandrakanth ^{[1
,2
]}

Sanchez, Washington Y. ^{[2
]}

Mohammed, Yousuf H. ^{[2
]}

Grice, Jeffrey E. ^{[2
]}

Roberts, Michael S. ^{[2
,3
]}

Barnard, Ross T. ^{[1
]}

机构：

[1] Univ Queensland, Australian Infect Dis Res Ctr, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Translat Res Inst, Sch Med, Therapeut Res Ctr, 37 Kent St, Woolloongabba, Qld 76131, Australia

[3] Univ South Australia, Sch Pharm & Med Sci, City East Campus,North Terrace, Adelaide, SA 5001, Australia

来源：

MAGNESIUM RESEARCH | 2016年 / 29卷 / 02期

关键词：

magnesium; hair follicle; multiphoton microscopy; mag-fura-2; PENETRATION; DEFICIENCY; DELIVERY; CHARGE;

D O I：

10.1684/mrh.2016.0402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnesium is an important micronutrient essential for various biological processes and its deficiency has been linked to several inflammatory disorders in humans. Topical magnesium delivery is one of the oldest forms of therapy for skin diseases, for example Dead Sea therapy and Epsom salt baths. Some anecdotal evidence and a few published reports have attributed amelioration of inflammatory skin conditions to the topical application of magnesium. On the other hand, transport of magnesium ions across the protective barrier of skin, the stratum corneum, is contentious. Our primary aim in this study was to estimate the extent of magnesium ion permeation through human skin and the role of hair follicles in facilitating the permeation. Upon topical application of magnesium solution, we found that magnesium penetrates through human stratum corneum and it depends on concentration and time of exposure. We also found that hair follicles make a significant contribution to magnesium penetration.

引用

页码：35 / 42

页数：8

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