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- [1] Efficacy and safety of the glucagon receptor antagonist, MK-0893, in combination with metformin or sitagliptin in patients with type 2 diabetes mellitus[J]. DIABETOLOGIA, 2011, 54 : S86 - S87Engel, S. S.Teng, R.Edwards, R. J.Davies, M. J.Kaufman, K. D.Goldstein, B. J.
- [2] Efficacy and Tolerability of MK-0893, a Glucagon Receptor Antagonist (GRA), in Patients with Type 2 Diabetes (T2DM)[J]. DIABETES, 2011, 60 : A85 - A85Engel, Samuel S.Xu, LeiAndryuk, Paula J.Davies, Michael J.Amatruda, JohnKaufman, KeithGoldstein, Barry J.
- [3] Inhibition of Glucagon-Induced Hyperglycemia Predicts Glucose Lowering Efficacy of a Glucagon Receptor Antagonist, MK-0893, in Type 2 Diabetes (T2DM)[J]. DIABETES, 2011, 60 : A85 - A86Ruddy, MarcellaPramanik, BarnaliLunceford, JaredLi, SusieCilissen, CarolineStoch, S. AubreyWagner, JohnAmatruda, JohnHerman, GaryKaufman, Keith
- [4] Discovery of a novel glucagon receptor antagonist for the treatment of type II diabetes[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247Xu, LiboFarthing, AmyLin, SongnianZhang, FengqiStevenson, ChristianUllman, AndrewLiang, RuiLight, DavidMetzger, EdwardDewnani, SunitaLiao, XibinKats-Kagan, RomanParmee, EmmaTata, James R.Jiang, GuoqiangQureshi, Sajjad A.Yang, XiaodongChicchi, Gary G.Tota, LaurieBansal, AlkaBrady, EdwardTrujillo, MariaSalituro, GinoMiller, CoreyZhang, Bei
- [5] Recovery from Hypoglycemia in Healthy Subjects Is Preserved Despite Glucagon Receptor Blockade by MK-0893[J]. DIABETES, 2011, 60 : A137 - A137Troyer, Matthew D.Hompesch, MarcusPramanik, BarnaliZheng, WeiWin, KhinDunbar, StephanieLi, SusieRuddy, MarcellaAmatruda, JohnKaufman, KeithWagner, JohnStoch, S. Aubrey
- [6] Recovery from Hypoglycemic Clamp in Type 2 Diabetes (T2DM) Patients during β-Adrenergic Blockade Plus Glucagon Receptor Blockade with MK-0893[J]. DIABETES, 2011, 60 : A137 - A137Troyer, Matthew D.Hompesch, MarcusJax, ThomasPramanik, BarnaliLiu, FangMorrow, LindaWin, KhinReynders, TomLiu, ChengchengEngel, SamuelHeise, TimMaliwat, ElsaDenney, William S.Kelley, David E.Wagner, John A.Stoch, S. Aubrey
- [7] Discovery of a Novel Glucagon Receptor Antagonist N-[(4-{(1S)-1-[3-(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (13) : 6137 - 6148Xiong, YushengGuo, JianCandelore, Mari R.Liang, RuiMiller, CoreyDallas-Yang, QingJiang, GuoqiangMcCann, Peggy E.Qureshi, Sajjad A.Tong, XinchunXu, Shiyao SherrieShang, JackieVincent, Stella H.Tota, Laurie M.Wright, Michael J.Yang, XiaodongZhang, Bei B.Tata, James R.Parmee, Emma R.
- [8] Discovery of potent glucagon receptor antagonists for the treatment of type 2 diabetes[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253Xu, GuozhangGaul, MichaelSong, FengbinZhao, BaopingLiang, YinDu, FuyongDiloreto, KarenHuebert, NormanShook, BrianRentzeperis, DennisSantulli, RosemaryEckardt, AnnetteSmith, CharlesDemarest, Keith
- [9] Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of and Diabetes[J]. ACS MEDICINAL CHEMISTRY LETTERS, 2022, 13 (08): : 1248 - 1254Palani, AnandanNawrocki, Andrea R.Orvieto, FedericaBianchi, ElisabettaMandic, EmanuelaPessi, AntonelloHuang, ChunhuiDeng, QiaolinToussaint, NathalieWalsh, ErikaReddy, VijayAshley, EricHe, HuaibingMumick, SheenaHawes, BrianMarsh, DonaldErion, MarkNargund, RaviCarrington, Paul E.
- [10] Glucagon Receptor Antagonists for Type II Diabetes[J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 43, 2008, 43 : 119 - 137DeMong, Duane E.Miller, Michael W.Lachowicz, Jean E.