Efficacy and safety of the glucagon receptor antagonist, MK-0893, in combination with metformin or sitagliptin in patients with type 2 diabetes mellitus

被引：0
|
作者：
Engel, S. S. [1 ]
Teng, R. [1 ]
Edwards, R. J. [1 ]
Davies, M. J. [1 ]
Kaufman, K. D. [1 ]
Goldstein, B. J. [1 ]
机构：
[1] Merck Sharp & Dohme Corp, Whitehouse Stn, NJ USA
来源：
DIABETOLOGIA | 2011年 / 54卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
191
引用
收藏
页码：S86 / S87
页数：2
相关论文
共 50 条
  • [1] Discovery of MK-0893: A glucagon receptor antagonist for the treatment of type II diabetes
    Parmee, Emma R.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [2] Efficacy and Tolerability of MK-0893, a Glucagon Receptor Antagonist (GRA), in Patients with Type 2 Diabetes (T2DM)
    Engel, Samuel S.
    Xu, Lei
    Andryuk, Paula J.
    Davies, Michael J.
    Amatruda, John
    Kaufman, Keith
    Goldstein, Barry J.
    [J]. DIABETES, 2011, 60 : A85 - A85
  • [3] Inhibition of Glucagon-Induced Hyperglycemia Predicts Glucose Lowering Efficacy of a Glucagon Receptor Antagonist, MK-0893, in Type 2 Diabetes (T2DM)
    Ruddy, Marcella
    Pramanik, Barnali
    Lunceford, Jared
    Li, Susie
    Cilissen, Caroline
    Stoch, S. Aubrey
    Wagner, John
    Amatruda, John
    Herman, Gary
    Kaufman, Keith
    [J]. DIABETES, 2011, 60 : A85 - A86
  • [4] Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus
    Scheen, Andre J.
    Charpentier, Guillaume
    Ostgren, Carl Johan
    Hellqvist, Asa
    Gause-Nilsson, Ingrid
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2010, 26 (07) : 540 - 549
  • [5] Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus
    Ballav, Chitrabhanu
    Gough, Stephen C. L.
    [J]. CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES, 2013, 6 : 25 - 37
  • [6] Safety and Efficacy of Sitagliptin Added to the Combination of Sulfonylurea and Metformin in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control
    Round, Elizabeth
    Shentu, Yue
    Golm, Gregory T.
    O'Neill, Edward A.
    Gantz, Ira
    Engel, Samuel S.
    Kaufman, Keith D.
    Goldstein, Barry J.
    [J]. DIABETES, 2013, 62 : A299 - A299
  • [7] Efficacy, Safety and Treatment Satisfaction of Glimepiride vs Sitagliptin in Combination with Metformin in Type 2 Diabetes Mellitus
    Kumar, Subodh
    Pathak, Anuj Kumar
    Saikia, Dibyajyoti
    Kumar, Amish
    [J]. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015, 9 (12) : FC07 - FC10
  • [8] Efficacy and safety of metformin-sitagliptin combination for the treatment of patients with diabetes mellitus and obesity
    Ametov, A. S.
    Pakus, E. N.
    [J]. DIABETES MELLITUS, 2010, 13 (03): : 62 - 65
  • [9] Recovery from Hypoglycemic Clamp in Type 2 Diabetes (T2DM) Patients during β-Adrenergic Blockade Plus Glucagon Receptor Blockade with MK-0893
    Troyer, Matthew D.
    Hompesch, Marcus
    Jax, Thomas
    Pramanik, Barnali
    Liu, Fang
    Morrow, Linda
    Win, Khin
    Reynders, Tom
    Liu, Chengcheng
    Engel, Samuel
    Heise, Tim
    Maliwat, Elsa
    Denney, William S.
    Kelley, David E.
    Wagner, John A.
    Stoch, S. Aubrey
    [J]. DIABETES, 2011, 60 : A137 - A137
  • [10] Efficacy and safety of titrated canagliflozin in patients with type 2 diabetes mellitus inadequately controlled on metformin and sitagliptin
    Rodbard, H. W.
    Seufert, J.
    Aggarwal, N.
    Cao, A.
    Fung, A.
    Pfeifer, M.
    Alba, M.
    [J]. DIABETES OBESITY & METABOLISM, 2016, 18 (08): : 812 - 819
12345