FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria

被引：62

作者：

Sun, Hongcheng ^{[1
]}

Teng, Mujian ^{[2
]}

Liu, Jie ^{[2
]}

Jin, Dong ^{[3
]}

Wu, Junyi ^{[1
]}

Yan, Dongwang ^{[1
]}

Fan, Junwei ^{[1
]}

Qin, Xuebin ^{[4
]}

Tang, Huamei ^{[5
]}

Peng, Zhihai ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Affiliated Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China

[2] Shangdong Univ, Affiliated Qianfoshan Hosp, Dept Hepatobiliary & Pancreat Surg, Jinan 250014, Shandong, Peoples R China

[3] Ningxia Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Yinchuan 750004, Ningxia Prov, Peoples R China

[4] Brigham & Womens Hosp, Dept Medicine, Boston, MA 02139 USA

[5] Shanghai Jiao Tong Univ, Sch Med, Affiliated Peoples Hosp 1, Dept Pathol, Shanghai 200080, Peoples R China

来源：

CANCER LETTERS | 2011年 / 306卷 / 02期

关键词：

Hepatocellular carcinoma; Orthotopic liver transplantation; FOXM1; Biomarker; TRANSCRIPTION FACTOR; EXPANSION; INVASION; IMPACT;

D O I：

10.1016/j.canlet.2011.03.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Molecular biomarker has been proposed to improve patient selection and post-transplant prognostication, but rare achievement has been made. In the present study, Forkhead box M1 (FOXM1) expression and its prognostic role have been investigated in hepatocellular carcinoma (HCC) treated by orthotopic liver transplantation (OLT). We found that the notably higher level of FOXM1 in tumors was associated with malignant pathological features of HCC and unfavorable outcome after OLT. The status of FOXM1 expression combined with the Milan criteria could make the prognostication more accurate and may be of particular interest for expanding the criteria in selecting transplant candidates. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：214 / 222

页数：9

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