This meta-analysis aimed to address the association between personality traits and conflict handling styles. ProQuest, PsycINFO, Scopus, and Web of science and also Microsoft Academic, Science.gov, Science open were searched for all published and non-published studies through 17 October 2018. A literature search located 20 eligible studies, and 5337 total participants. The results of this review show that neuroticism and agreeableness are positively related to avoiding style. The positive associations are observed between agreeableness, extroversion, openness to experience, and conscientiousness with compromising style. There exist positive and negative relations between extroversion and agreeableness with dominating style, respectively. A positive link is identified between agreeableness and obliging style. Finally, agreeableness, extroversion, openness to experience, and conscientiousness are positively correlated with integrating style and neuroticism is negatively related to integrating style. The findings of moderator analysis indicate that there is a different pattern between work and academic setting concerning the relationship between agreeableness with compromising. Similarly, the results of the academic setting yielded the different population as the work setting when it comes to the link between neuroticism and compromising style.