Replication of bovine herpesvirus type 4 in human cells in vitro

被引：30
|
作者：
Egyed, L [1 ]
机构：
[1] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 1998年 / 36卷 / 07期
关键词：
D O I：
10.1128/JCM.36.7.2109-2111.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A reference strain (Movar 33/63) of bovine herpesvirus type 4 (BHV-4) was inoculated into 14 different human cell lines and five primary cell cultures representing various human tissues. BHV-4 replicated in two embryonic lung fell lines, MRC-5 and Wistar-38, and in a giant-cell glioblastoma cell culture. Cytopathic effect and intranuclear inclusion bodies were observed in these cells. PCR detected a 10,000-times-higher level of BHV-4 DNA. Titration of the supernatant indicated a 100-fold increase of infections particles. Since this is the first bovine (human herpesvirus 8 and Epstein-Barr virus related) herpesvirus which replicates on human cells in vitro, the danger of possible human BHV-4 infection should not be ignored.
引用
收藏
页码：2109 / 2111
页数：3
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