Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study

被引：4

作者：

Healey, Catherine S. ^{[1
]}

Ahmed, Shahana ^{[1
]}

O'Mara, Tracy A. ^{[2
,4
]}

Ferguson, Kaltin ^{[2
]}

Lambrechts, Diether ^{[5
]}

Garcia-Dios, Diego A. ^{[5
,6
]}

Vergote, Ignace ^{[6
]}

Amant, Frederic ^{[6
]}

Howarth, Kimberley ^{[7
]}

Gorman, Maggie ^{[7
]}

Hodgson, Shirley ^{[8
]}

Tomlinson, Ian ^{[7
]}

Yang, Hannah P. ^{[9
]}

Lissowska, Jolanta ^{[10
,11
]}

Brinton, Louise A. ^{[9
]}

Chanock, Stephen ^{[9
]}

Garcia-Closas, Montserrat ^{[9
]}

Hall, Per ^{[12
]}

Liu, Jianjun ^{[13
]}

Shah, Mitul

Pharoah, Paul D. P.

Thompson, Deborah J. ^{[14
]}

Rebbeck, Timothy R. ^{[15
]}

Strom, Brian L. ^{[15
]}

Dunning, Alison M. ^{[1
]}

Easton, Douglas F. ^{[14
]}

Spurdle, Amanda B. ^{[2
]}

机构：

[1] Univ Cambridge, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England

[2] Queensland Inst Med Res, Div Genet & Populat Hlth, Brisbane, Qld 4006, Australia

[3] Peter MacCallum Canc Ctr, Melbourne, Vic 3002, Australia

[4] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Hormone Dependent Canc Program, Brisbane, Qld 4059, Australia

[5] VIB, Vesalius Res Ctr, B-3000 Louvain, Belgium

[6] Univ Hosp Gasthuisberg, Dept Obstet & Gynecol, Div Gynecol Oncol, B-3000 Louvain, Belgium

[7] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[8] St George Hosp, Sch Med, Dept Clin Genet, London SW17 0RE, England

[9] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Rockville, MD 20852 USA

[10] Maria Sklodowska Curie Mem Canc Ctr, Dept Canc Epidemiol & Prevent, PL-02781 Warsaw, Poland

[11] Inst Oncol, PL-02781 Warsaw, Poland

[12] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

[13] Genome Inst Singapore, Singapore 138672, Singapore

[14] Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England

[15] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Abramson Canc Ctr, Philadelphia, PA 19104 USA

来源：

CARCINOGENESIS | 2011年 / 32卷 / 12期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; HORMONE-REPLACEMENT THERAPY; VARIANTS; ALLELES;

D O I：

10.1093/carcin/bgr214

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11 928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.

引用

页码：1862 / 1866

页数：5

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