Synthesis of novel 1,2,3-triazole derivatives of 2,3-dihydroquinazolin-4(1H)-one

被引：3

作者：

Mahdavi, Mohammad ^{[1
]}

Saeedi, Mina ^{[2
,3
]}

Karimi, Maryam ^{[4
,5
]}

Foroughi, Niloufar ^{[4
,5
]}

Hasanshahi, Fatemeh ^{[1
]}

Alinezhad, Heshmatollah ^{[6
]}

Foroumadi, Alireza ^{[4
,5
]}

Shafiee, Abbas ^{[4
,5
]}

Akbarzadeh, Tahmineh ^{[3
,7
]}

机构：

[1] Univ Tehran Med Sci, Fac Pharm, Int Campus TUMS IC, Tehran, Iran

[2] Univ Tehran Med Sci, Med Plants Res Ctr, Fac Pharm, Tehran, Iran

[3] Univ Tehran Med Sci, Persian Med & Pharm Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

[5] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

[6] Univ Mazandaran, Fac Chem, Babol Sar, Iran

[7] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran

来源：

MONATSHEFTE FUR CHEMIE | 2016年 / 147卷 / 12期

关键词：

Quinazolin-4(1H)-one; 1; 2; 3-Triazole; Click chemistry; Isatoic anhydride; QUINAZOLINONE DERIVATIVES; BIOLOGICAL EVALUATION; INHIBITORS; ANALOGS;

D O I：

10.1007/s00706-016-1739-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work reports an efficient route for the synthesis of novel 1,2,3-triazole derivatives of 2,3-dihydroquinazolin-4(1H)-one starting from isatoic anhydride via a three-step reaction. The resulting 2-amino-N-substituted benzamides from the reaction of isatoic anhydride and benzylamines underwent coupling cyclization reaction with 4-(prop-2-yn-1-yloxy)benzaldehyde, and then click reaction with in situ prepared organic azides afforded the title compounds in good yields.

引用

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页码：2151 / 2156

页数：6

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