Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats

被引：67
|
作者：
Yang, Lan [1 ]
Wang, Cheng-zhang [1 ]
Ye, Jian-zhong [1 ]
Li, Hai-tao [2 ]
机构：
[1] CAF, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China
[2] Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Ginkgo biloba; Polyprenols; Essentiale; Hepatoprotective; Antioxidant; CARBON-TETRACHLORIDE; RIFAMPICIN;
D O I：
10.1016/j.fitote.2011.04.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The hepatoprotective effects of polyprenols from Ginkgo biloba L leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：834 / 840
页数：7
相关论文
共 50 条
  • [21] Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats
    Verma, Nitin
    Khosa, R. L.
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2010, 47 (02): : 124 - 127
  • [22] Evaluation of Extracts of Seeds of Syzygium cumini L. for Hepatoprotective Activity Using CCl4-Induced Stressed Rats
    Islam, M.
    Hussain, K.
    Latif, A.
    Hashmi, F. K.
    Saeed, H.
    Bukhari, N. I.
    Hassan, S. S.
    Danish, M. Z.
    Ahmad, B.
    PAKISTAN VETERINARY JOURNAL, 2015, 35 (02) : 197 - 200
  • [23] Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat
    Sahreen, Sumaira
    Khan, Muhammad R.
    Khan, Rahmat A.
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 11
  • [24] Hepatoprotective Activity of Leaf Extract Laurus Nobilis L. against CCL4 Induced Hepatotoxicity in Rats
    Vardapetyan, H.
    Tiratsuyan, S.
    Hovhannisyan, A.
    3RD INTERNATIONAL CONFERENCE ON NANOTECHNOLOGIES AND BIOMEDICAL ENGINEERING, 2016, 55 : 419 - 423
  • [25] Hepatoprotective effects of Portulaca oleracea extract against CCl4-induced damage in rats
    Eidi, Akram
    Mortazavi, Pejman
    Moghadam, Jalal Zarringhalam
    Mardani, Parisa Mousavi
    PHARMACEUTICAL BIOLOGY, 2015, 53 (07) : 1042 - 1051
  • [26] HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF BALANITES AEGYPTIACA (L.) DEL AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
    Suky, T. Mayba Gnana
    Parthipan, B.
    Kingston, C.
    Mohan, V. R.
    Soris, P. Tresina
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (04): : 887 - 892
  • [27] Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat
    Sumaira Sahreen
    Muhammad R Khan
    Rahmat A Khan
    BMC Complementary and Alternative Medicine, 11
  • [28] Hepatoprotective effect of ethanolic extract of whole plant of Andrographis paniculata against CCl4-induced hepatotoxicity in rats
    Subramaniam S.
    Hedayathullah Khan H.B.
    Elumalai N.
    Sudha Lakshmi S.Y.
    Comparative Clinical Pathology, 2015, 24 (5) : 1245 - 1251
  • [29] Antibacterial/Antifungal Activity and Synergistic Interactions between Polyprenols and Other Lipids Isolated from Ginkgo Biloba L. Leaves
    Tao, Ran
    Wang, Cheng-Zhang
    Kong, Zhen-Wu
    MOLECULES, 2013, 18 (02): : 2166 - 2182
  • [30] Evaluation of Hepatoprotective Potential of Bougainvillea spectabilis Extracts against CCl4-Induced Hepatotoxicity
    Das, Prabhat Kumar
    Vaghela, Jai Singh
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2025, 59 (01) : 377 - 383
12345