Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats

被引：67
|
作者：
Yang, Lan [1 ]
Wang, Cheng-zhang [1 ]
Ye, Jian-zhong [1 ]
Li, Hai-tao [2 ]
机构：
[1] CAF, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China
[2] Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China
来源：
FITOTERAPIA | 2011年 / 82卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Ginkgo biloba; Polyprenols; Essentiale; Hepatoprotective; Antioxidant; CARBON-TETRACHLORIDE; RIFAMPICIN;
D O I：
10.1016/j.fitote.2011.04.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The hepatoprotective effects of polyprenols from Ginkgo biloba L leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：834 / 840
页数：7
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