Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan

被引：0
|
作者：
Onda, T
Tanaka, T
Takeda, O
Kitagawa, M
Kuwabara, Y
Yamamoto, H
Iinuma, K
Shimomura, K
机构：
[1] Jikei Univ, Sch Med, Dept Obstet & Gynaecol, Tokyo 105, Japan
[2] Fuji City Hosp, Fuji, Shizuoka, Japan
[3] Natl Ohkura Hosp, Tokyo, Japan
[4] Juntendo Univ, Sch Med, Tokyo 113, Japan
[5] Sapporo Med Univ, Sch Med, Sapporo, Hokkaido, Japan
[6] IG Clin, Tokyo, Japan
[7] Genzyme Japan KK, Tokyo, Japan
来源：
PRENATAL DIAGNOSIS | 1998年 / 18卷 / 09期
关键词：
triple-marker screening test; Down syndrome; prediction; accuracy; follow-up study;
D O I：
10.1002/(SICI)1097-0223(199809)18:9<956::AID-PD370>3.0.CO;2-R
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Based on 9350 pregnant Japanese women who were screened by serum triple-marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r=0.98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow-up study, implemented in our prospective intervention programme. (C) 1998 John Wiley & Sons, Ltd.
引用
收藏
页码：956 / 958
页数：3
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