Petrositis caused by fluconazole-resistant candida: case report and literature review

被引：2
|
作者：
Jin, Ling [1 ]
Liu, Shuangxi [1 ]
Tan, Shiwang [1 ]
Wang, Yang [1 ]
Zhao, Yumin [1 ]
Yu, Shaoqing [1 ]
机构：
[1] Tongji Univ, Tongji Hosp, Sch Med, Dept Otolaryngol, 389 Xincun Rd, Shanghai 200065, Peoples R China
来源：
BMC INFECTIOUS DISEASES | 2022年 / 22卷 / 01期
基金：
美国国家科学基金会;
关键词：
Petrositis; Gradenigo's syndrome; Candida; Diagnoses; Drug treatment; GRADENIGOS-SYNDROME; ANTIFUNGAL AGENTS; MECHANISMS; MUTATIONS;
D O I：
10.1186/s12879-022-07637-3
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background Petrositis is a rare and fatal complication associated with otitis media. It is most likely caused by bacterial infections, but in some cases it is caused by fungal infections. Case study The case in this report is associated with fungal petrositis. The clinical symptoms are: ear pain from chronic otitis media, severe headache, peripheral facial palsy and diplopia. The case was finally confirmed through imaging of middle ear, bacterial culture, pathology, and blood Metagenomic next-generation sequencing (mNGS) test. The patient was treated with sensitive antifungal drugs. Conclusion Drug treatment is conservative but efficient method in this case. mNGS can provide pathogenic reference, when antibiotic is not efficient enough for fungal infections or drug-resistant fungal infections cases. This allows we to adjust drug use for the treatment.
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页数：10
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