Long-term follow-up of adalimumab monotherapy for rheumatoid arthritis in Japanese patients: a report of six cases

被引：0

作者：

Ichinose, Kunihiro ^{[1
]}

Origuchi, Tomoki ^{[2
]}

Kawashiri, Shin-ya ^{[1
]}

Iwamoto, Naoki ^{[1
]}

Fujikawa, Keita ^{[1
]}

Aramaki, Toshiyuki ^{[1
]}

Kamachi, Makoto ^{[1
]}

Arima, Kazuhiko ^{[1
]}

Tamai, Mami ^{[1
]}

Nakamura, Hideki ^{[1
]}

Ida, Hiroaki ^{[1
]}

Kawakami, Atsushi ^{[1
]}

Eguchi, Katsumi ^{[1
]}

机构：

[1] Nagasaki Univ, Dept Rheumatol, Unit Translat Med, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Dept Phys Therapy, Unit Rehabil, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 02期

关键词：

Rheumatoid arthritis (RA); Adalimumab; Long-term; DAS28-CRP; ANTITUMOR NECROSIS FACTOR; MONOCLONAL-ANTIBODY; METHOTREXATE; RISK; TUBERCULOSIS; EFFICACY; THERAPY; DISEASE; SAFETY;

D O I：

10.1007/s00296-010-1770-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present six cases of patients with Japanese rheumatoid arthritis (RA) treated with a tumor necrosis factor (TNF)-alpha blocking agent, adalimumab as monotherapy for 220 weeks. All six patients were women, and the median age was 54.0 +/- A 7.07 years old. The median duration of the disease was 7.43 +/- A 11.1 years, and the median disease activity score (DAS28-CRP) was 5.35 +/- A 0.69. Three of six patients were able to continue to receive this treatment for 220 weeks successfully, and the DAS28-CRP decreased to 1.89 +/- A 0.75. Two patients withdrew because of lack of efficacy, and one patient withdrew because of adverse events (non-Hodgkin lymphoma). Adalimumab resulted in a sustained clinical response in RA patients during 220-week follow-up.

引用

页码：483 / 487

页数：5

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