One-pot three-component synthesis of functionalized spirolactones by means of reaction between aromatic ketones, dimethyl acetylenedicarboxylate, and N-heterocycles

被引：48
|
作者：
Maghsoodlou, Malek Taher [1 ]
Habibi-Khorassani, Sayyed Mostafa [1 ]
Moradi, Abbas [2 ]
Hazeri, Nourallah [1 ]
Davodi, Amir [1 ]
Sajadikhah, Seyed Sajad [1 ]
机构：
[1] Univ Sistan & Baluchestan, Dept Chem, Zahedan, Iran
[2] Univ Birjand, Dept Chem, Birjand, Iran
来源：
TETRAHEDRON | 2011年 / 67卷 / 44期
关键词：
Spirolactone; N-Heterocycle; DMAD; Multi-component reaction; GAMMA-LACTONES; FACILE SYNTHESIS; DERIVATIVES; ACID; ISOCYANIDES;
D O I：
10.1016/j.tet.2011.09.017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and convenient one-pot multi-component reaction has been described for the synthesis of functionalized spirolactones. This strategy demonstrated three-component reaction between aromatic ketones (11H-indeno[1,2-b]quinoxalin-11-one) and dimethyl acetylenedicarboxylate (DMAD) in the presence of N-heterocycles, such as pyridine, quinoline, and isoquinoline in CH2Cl2 at ambient temperature without use of any catalyst or activator. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8492 / 8495
页数：4
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