Regulation of energy consumption in cardiac muscle: analysis of isometric contractions

被引:31
|
作者
Landesberg, A [1 ]
Sideman, S [1 ]
机构
[1] Heart Syst Res Ctr, Julius Silver Inst, Dept Biomed Engn, IL-32000 Haifa, Israel
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1999年 / 276卷 / 03期
关键词
calcium control; cooperativity; intracellular; sarcomere;
D O I
10.1152/ajpheart.1999.276.3.H998
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The well-known linear relationship between oxygen consumption and force-length area or the force-time integral is analyzed here for isometric contractions. The analysis, which is based on a biochemical model that couples calcium kinetics with cross-bridge cycling, indicates that the change in the number of force-generating cross bridges with the change in the sarcomere length depends on the force generated by the cross bridges. This positive-feedback phenomenon is consistent with our reported cooperativity mechanism, whereby the affinity of the troponin for calcium and, hence, cross-bridge recruitment depends on the number of force-generating cross bridges. Moreover, it is demonstrated that a model that does not include a feedback mechanism cannot describe the dependence of energy consumption on the loading conditions. The cooperativity mechanism, which has been shown to determine the force-length relationship and the related Frank-Starling law, is shown here to provide the basis for the regulation of energy consumption in the cardiac muscle.
引用
收藏
页码:H998 / H1011
页数:14
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