Design and automated production of 11C-alpha-methyl-L-tryptophan (11C-AMT)

被引：14

作者：

Huang, Xuan ^{[1
]}

Xiao, Xia ^{[1
,2
]}

Gillies, Robert J. ^{[1
]}

Tian, Haibin ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Imaging & Metab, Tampa, FL 33612 USA

[2] Guangzhou Univ Chinese Med, Dept Pathol, Guangzhou, Guangdong, Peoples R China

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2016年 / 43卷 / 05期

关键词：

METHYL-L-TRYPTOPHAN; SEROTONIN SYNTHESIS; HUMAN BRAIN; METABOLISM;

D O I：

10.1016/j.nucmedbio.2016.02.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

C-11-alpha-methyl-L-tryptophan ([C-11]AMT), a tryptophan metabolism PET tracer, has successfully been employed for brain serotonin pathway and indoleamine 2,3-dioxygenase (IDO) pathway related tumor imaging. We here report a reliable, automated procedure for routine synthesis of [C-11]AMT based on an Eckert and Ziegler Modular-Lab system. The semi-preparative HPLC was incorporated into the system to improve chemical purity and specific activity. The 6-step radiosynthesis followed by HPLC-purification provided [(11)]AMT in 53 +/- 1.2% (n = 6, non-decay-corrected) overall radiochemical yield with radiochemical purity >99% and specific activity of 35-116 GBq/mu mol. Usually, 2.95 +/- 0.65 GBq (n = 6, EOS) patient ready dose was produced from about 55.5 GBq [C-11]CO2 in 50 min. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：303 / 308

页数：6

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