Expression and inducibility of cytoprotective heat shock proteins in the bone marrow of patients with myelodysplastic syndrome: correlation with disease progression

被引：0

作者：

Michalopoulou, Sotiria ^{[1
,2
]}

Micheva, Ilina

Karakantza, Marina

Kouraklis-Symeonidis, Alexandra

Mouzaki, Athanasia

Zoumbos, Nicholas C.

机构：

[1] Univ Patras, Sch Med, Dept Internal Med, Div Haematol, GR-26500 Patras, Greece

[2] Univ Patras, Univ Hosp, GR-26500 Patras, Greece

来源：

HAEMATOLOGICA | 2006年 / 91卷 / 12期

关键词：

myelodysplastic syndrome; heat shock proteins; bone marrow; apoptosis; cytokines; disease progression;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We determined the intracellular expression and inducibility of heat shock proteins (Hsps) 72, 73 and 27 in the bone marrow of patients with myelodysplastic syndrome (MDS) and controls. Hsps were overexpressed in MDS marrow especially in advanced disease, providing resistance to induction of apoptosis. These data suggest that Hsps could be implicated in the progression of MDS to acute myeloid leukemia.

引用

页码：1714 / 1716

页数：3

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