Expression and inducibility of cytoprotective heat shock proteins in the bone marrow of patients with myelodysplastic syndrome: correlation with disease progression

被引：0
|
作者：
Michalopoulou, Sotiria [1 ,2 ]
Micheva, Ilina
Karakantza, Marina
Kouraklis-Symeonidis, Alexandra
Mouzaki, Athanasia
Zoumbos, Nicholas C.
机构：
[1] Univ Patras, Sch Med, Dept Internal Med, Div Haematol, GR-26500 Patras, Greece
[2] Univ Patras, Univ Hosp, GR-26500 Patras, Greece
来源：
HAEMATOLOGICA | 2006年 / 91卷 / 12期
关键词：
myelodysplastic syndrome; heat shock proteins; bone marrow; apoptosis; cytokines; disease progression;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We determined the intracellular expression and inducibility of heat shock proteins (Hsps) 72, 73 and 27 in the bone marrow of patients with myelodysplastic syndrome (MDS) and controls. Hsps were overexpressed in MDS marrow especially in advanced disease, providing resistance to induction of apoptosis. These data suggest that Hsps could be implicated in the progression of MDS to acute myeloid leukemia.
引用
收藏
页码：1714 / 1716
页数：3
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