Metabolites of isocorynoxeine in rats after its oral administration

被引：7
|
作者：
Chen, Ya-Ping [1 ,2 ]
Lu, Min-Nan [3 ]
Hao, Jing-Chao [1 ,2 ]
Li, Mei-Hong [1 ,2 ]
Hattori, Masao [4 ]
Wang, Wei [1 ,2 ,4 ]
机构：
[1] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
[2] Kunming Med Univ, Yunnan Prov Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
[3] Kunming Med Univ, Expt Ctr Med Sci Res, Kunming 650500, Peoples R China
[4] Toyama Univ, Inst Nat Med, Div Metab Engn, Sugitani, Toyama 2630, Japan
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2015年 / 17卷 / 04期
关键词：
metabolites; isocorynoxeine; structure elucidation; CHROMATOGRAPHY-MASS-SPECTROMETRY; UNCARIA-RHYNCHOPHYLLA; LIQUID-CHROMATOGRAPHY; OXINDOLE ALKALOIDS; QUANTIFICATION; ISORHYNCHOPHYLLINE; IDENTIFICATION; TOMENTOSA; LEAVES; HOOKS;
D O I：
10.1080/10286020.2014.1003182
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This work presents the metabolites of isocorynoxeine (ICOR), which is one of four bioactive tetracyclic oxindole alkaloids isolated from Uncaria hooks used commonly in the traditional Chinese medicines and Kampo medicines. After oral administration of 40mgkg(-1) ICOR to rats, bile was drained and analyzed by LC-MS. Two phase I metabolites, namely 11-hydroxyisocorynoxeine (M1) and 10-hydroxyisocorynoxeine (M2), and two phase II metabolites, namely 11-hydroxyisocorynoxeine 11-O-beta-d-glucuronide (M3) and 10-hydroxyisocorynoxeine 10-O-beta-d-glucuronide (M4), were isolated from rat excreta and bile, respectively, whose structures were elucidated on the basis of CD, NMR, and MS.
引用
收藏
页码：384 / 390
页数：7
相关论文
共 50 条
  • [21] SERUM CONCENTRATIONS OF MORPHINE AND ITS MAJOR METABOLITES AFTER ORAL-ADMINISTRATION
    HAND, CW
    MOORE, RA
    JONES, S
    MCQUAY, HJ
    CLINICAL CHEMISTRY, 1987, 33 (06) : 969 - 969
  • [22] Pharmacokinetics of Cyadox and Its Major Metabolites in Swine After Intravenous and Oral Administration
    Zhao Ning
    Wang Lin
    Lu Xiao-xiong
    Jia Hui-qin
    Fang Bing-hu
    Zeng Zhen-ling
    Ding Huan-zhong
    JOURNAL OF INTEGRATIVE AGRICULTURE, 2013, 12 (03) : 495 - 501
  • [23] Pharmacokinetics and Metabolism of Toltrazuil and Its Major Metabolites after Oral Administration in Broilers
    Kim, Myoung-Seok
    Park, Byung-Kwon
    Hwang, Youn-Hwan
    Song, In-Bae
    Kim, Tea-Won
    Cho, Jung-Hee
    Ham, Sung-Ho
    Lim, Jong-Hwan
    Yun, Hyo-In
    JOURNAL OF POULTRY SCIENCE, 2013, 50 (03): : 257 - 261
  • [24] Pharmacokinetics of Quinocetone and Its Major Metabolites in Swine After Intravenous and Oral Administration
    ZHONG Jia-lin
    Agricultural Sciences in China, 2011, 10 (08) : 1292 - 1300
  • [25] Pharmacokinetics of Quinocetone and Its Major Metabolites in Swine After Intravenous and Oral Administration
    Zhong Jia-lin
    Zhang Gui-jun
    Shen Xiang-guang
    Wang Lin
    Fang Bing-hu
    Ding Huan-zhong
    AGRICULTURAL SCIENCES IN CHINA, 2011, 10 (08): : 1292 - 1300
  • [26] Tissue distribution of nobiletin and its metabolites in mice after oral administration of nobiletin
    Wang, Minqi
    Zheng, Jinkai
    Zhong, Zhimei
    Song, Mingyue
    Wu, Xian
    FASEB JOURNAL, 2013, 27
  • [27] Excretion profile of boldenone and its metabolites after oral administration to veal calves
    Ferretti, G.
    Palleschi, L.
    Marchiafava, C.
    Quadri, F. delli
    Fantozzi, L.
    Ferranti, C.
    Cammarata, P.
    Macri, A.
    Montesissa, C.
    Draisci, R.
    ANALYTICA CHIMICA ACTA, 2007, 589 (02) : 269 - 274
  • [28] Pharmacokinetics of Hydroxytyrosol and Its Sulfate and Glucuronide Metabolites after the Oral Administration of Table Olives to Sprague-Dawley Rats
    Kundisova, Ivana
    Colom, Helena
    Juan, M. Emilia
    Planas, Joana M.
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (04) : 2154 - 2164
  • [29] Identification and Comparison of Metabolites After Oral Administration of Essential Oil of Ligusticum chuanxiong or its Major Constituent Ligustilide in Rats
    Ding, Chunguang
    Sheng, Yuxin
    Zhang, Yinghao
    Zhang, Jinlan
    Du, Guanhua
    PLANTA MEDICA, 2008, 74 (14) : 1684 - 1692
  • [30] Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration ofloxoprofen in rats: Evidence for extrahepatic
    Lee, Kyeong-Ryoon
    Koo, Tae-Sung
    Kim, Dae-Duk
    Shim, Chang-Koo
    Chung, Suk-Jae
    DRUG METABOLISM REVIEWS, 2006, 38 : 53 - 53
12345