Reactive ester-urethane prepolymer as bioadhesive: synthesis and evaluation

Reactive urethane prepolymer, as a base material for the process of gluing in medicine. has been studied. For this purpose castor oil and toluene diisocyanate (TDI) were used as polyol and diisocyanate components to synthesize the isocyanate terminated urethane prepolymer. The molecular structure of this prepolymer was investigated by infrared spectroscopy ((FTIR) and vapour pressure osmometry (VPO). The obtained infrared spectrum confirmed the presence of free NCO groups bonded to the prepolymer backbone. The wetting behaviour of the synthesized prepolymer was evaluated by surface tension measurement. The surface behaviour of the cured thin films of the prepolymer was characterized using contact angle measurements. The cytotoxicity of the cured prepolymer film was evaluated by in vitro cell culture experiment. Results showed a compatible cell response with no signs of toxicity.