Construction of Protein Phosphorylation Network Based on Boolean Network Methods Using Proteomics Data

被引：0

作者：

Yu, Han ^{[1
,2
]}

Zhao, Yaou ^{[1
,2
]}

Han, Shiyuan ^{[1
,2
]}

Chen, Yuehui ^{[1
,2
]}

He, Wenxing ^{[3
]}

Dong, Likai ^{[1
]}

机构：

[1] Univ Jinan, Sch Informat Sci & Engn, Jinan 250022, Peoples R China

[2] Shandong Prov Key Lab Network Based Intelligent C, Jinan 250022, Peoples R China

[3] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China

来源：

INTELLIGENT COMPUTING THEORIES AND APPLICATION, ICIC 2016, PT I | 2016年 / 9771卷

关键词：

PTM; Computational intelligence; Phosphorylation network; PBIL; TDE; DIFFERENTIAL EVOLUTION;

D O I：

10.1007/978-3-319-42291-6_26

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

Post-translational Modification (PTM) of Proteins is a key biological process in the regulation of protein function. This paper discusses the problem of construction of PTM network based on the reverse engineering principles, which is constructed by using PBIL and TDE algorithms. Experiments which are based on two well-known pathways by the time series data of protein phosphorylation data show that the new method can be successfully validated and further reveal the regulation of protein phosphorylation.

引用

页码：268 / 277

页数：10

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