Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives

被引：46

作者：

Hatti, Islavathu ^{[1
]}

Sreenivasulu, Reddymasu ^{[1
]}

Jadav, Surender Singh ^{[2
]}

Jayaprakash, Venkatesan ^{[2
]}

Kumar, C. Ganesh ^{[3
]}

Raju, Rudraraju Ramesh ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Guntur 522510, Andhra Pradesh, India

[2] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

[3] CSIR Indian Inst Chem Technol, Ctr Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 08期

关键词：

Podophyllotoxin; Knoevenagel condensation; Etoposide; Cytotoxicity; Docking studies; FACILE SYNTHESIS; PODOPHYLLOTOXIN; ANALOGS; ASSAY;

D O I：

10.1007/s00044-015-1375-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesized nine aza-podophyllotoxin derivatives (8a-f, 10, 12 and 14) have been evaluated for their cytotoxicity in a panel of tumor cancer cell lines (Zr-75-1, MCF7, KB, Gurav, DWD, Colo-205, A-549 and Hop62). Among them, 8a and 8b compounds show stronger growth inhibition activity than the standard drug etoposide. Further, molecular docking simulations were carried out against human topoisomerase II, a putative target for these classes of molecules.

引用

页码：3305 / 3313

页数：9

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