Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives

被引：46

作者：

Hatti, Islavathu ^{[1
]}

Sreenivasulu, Reddymasu ^{[1
]}

Jadav, Surender Singh ^{[2
]}

Jayaprakash, Venkatesan ^{[2
]}

Kumar, C. Ganesh ^{[3
]}

Raju, Rudraraju Ramesh ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Guntur 522510, Andhra Pradesh, India

[2] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

[3] CSIR Indian Inst Chem Technol, Ctr Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 08期

关键词：

Podophyllotoxin; Knoevenagel condensation; Etoposide; Cytotoxicity; Docking studies; FACILE SYNTHESIS; PODOPHYLLOTOXIN; ANALOGS; ASSAY;

D O I：

10.1007/s00044-015-1375-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesized nine aza-podophyllotoxin derivatives (8a-f, 10, 12 and 14) have been evaluated for their cytotoxicity in a panel of tumor cancer cell lines (Zr-75-1, MCF7, KB, Gurav, DWD, Colo-205, A-549 and Hop62). Among them, 8a and 8b compounds show stronger growth inhibition activity than the standard drug etoposide. Further, molecular docking simulations were carried out against human topoisomerase II, a putative target for these classes of molecules.

引用

页码：3305 / 3313

页数：9

共 50 条

[1] Synthesis, cytotoxic activity and docking studies of new 4-aza-podophyllotoxin derivatives
Islavathu Hatti
Reddymasu Sreenivasulu
Surender Singh Jadav
Venkatesan Jayaprakash
C. Ganesh Kumar
Rudraraju Ramesh Raju
Medicinal Chemistry Research, 2015, 24 : 3305 - 3313
[2] Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents
Nguyen, Ha Thanh
Van, Ket Tran
Pham-The, Hai
Braire, Julien
Thi, Phuong Hoang
Nguyen, Tuan Anh
Thi, Quynh Giang Nguyen
Dang Thi, Tuyet Anh
Le-Nhat-Thuy, Giang
Le Thi, Tu Anh
Ngoc, Doan Vu
Van, Tuyen Nguyen
RSC ADVANCES, 2024, 14 (03) : 1838 - 1853
[3] Regioselective Synthesis and in Vitro Anticancer Activity of 4-Aza-podophyllotoxin Derivatives Catalyzed by L-Proline
Shi, Chunling
Wang, Juxian
Chen, Hui
Shi, Daqing
JOURNAL OF COMBINATORIAL CHEMISTRY, 2010, 12 (04): : 430 - 434
[4] An Efficient One-Pot Multicomponent Synthesis of 4-Aza-Podophyllotoxin Derivatives in Ionic Liquid
Naeimi, Hossein
Rashid, Zahra
Zarnani, Amir Hassan
Ghahremanzadeh, Ramin
JOURNAL OF CHEMISTRY, 2013, 2013
[5] Facile synthesis of new 4-aza-podophyllotoxin analogs via microwave-assisted multi-component reactions and evaluation of their cytotoxic activity
Shi, Feng
Zeng, Xiao-Ning
Zhang, Ge
Ma, Ning
Jiang, Bo
Tu, Shujiang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (23) : 7119 - 7123
[6] A simple procedure for the synthesis of 4-aza-podophyllotoxin derivatives in water under microwave irradiation conditions
Tu, Shujiang
Zhang, Yan
Zhang, Junyong
Jiang, Bo
Jia, Runhong
Zhang, Jinpeng
Ji, Shunjun
SYNLETT, 2006, (17) : 2785 - 2790
[7] Synthesis, Molecular Docking, and Cytotoxic Evaluation of Fluorinated Podophyllotoxin Derivatives
Thanh, Nguyen Ha
Bao, Le Quang
Pham-The, Hai
Anh, Dang Thi Tuyet
Kiem, Phan Van
NATURAL PRODUCT COMMUNICATIONS, 2023, 18 (02)
[8] Mechanistic investigation and implications of a sacrificial aniline for the tandem cascade synthesis of 4-aza-podophyllotoxin analogues
Jeedimalla, Nagalakshmi
Johns, Jennifer
Roche, Stephane P.
TETRAHEDRON LETTERS, 2013, 54 (44) : 5845 - 5848
[9] Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin
Zhang, Zhi-Jun
Tian, Jing
Wang, Li-Ting
Wang, Mei-Juan
Nan, Xiang
Yang, Liu
Liu, Ying-Qian
Morris-Natschke, Susan L.
Lee, Kuo-Hsiung
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (01) : 204 - 210
[10] Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives
Li, Wen-Qun
Wang, Xu-Li
Qian, Keduo
Liu, Ying-Qian
Wang, Chih-Ya
Yang, Liu
Tian, Jin
Morris-Natschke, Susan L.
Zhou, Xing-Wen
Lee, Kuo-Hsiung
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (08) : 2363 - 2369

← 1 2 3 4 5 →