The Effects of a Serious Game on Depressive Symptoms and Anxiety in Breast Cancer Patients with Depression: A Pilot Study Using Functional Magnetic Resonance Imaging

被引:17
|
作者
Kim, Sun Mi [1 ]
Kim, Hee-Jun [2 ]
Hwang, Hyun Chan [1 ]
Hong, Ji Sun [1 ]
Bae, Sujin [1 ]
Min, Kyoung Joon [1 ]
Han, Doug Hyun [1 ]
机构
[1] Chung Ang Univ, Coll Med, Dept Psychiat, 102 Heukseok Ro, Seoul 06973, South Korea
[2] Chung Ang Univ, Coll Med, Dept Internal Med, Div Hematooncol, Seoul, South Korea
关键词
Breast cancer; Depression; Default mode network; Insula; Salience network; Serious game; DEFAULT MODE NETWORK; VIRTUAL-REALITY; COMPUTER GAMES; YOUNG-ADULTS; VIDEO GAME; CONNECTIVITY; ADOLESCENTS; INVENTORY; PREVALENCE; DISORDERS;
D O I
10.1089/g4h.2017.0183
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: Depression is common in cancer patients. We investigated the effects of playing a serious game in breast cancer patients with mild to moderate depression using functional neuroimaging. Materials and Methods: Thirty-five participants were randomly assigned to the Game group and the Nongame group, and fifteen participants in each group completed the study protocol. Participants in the Game group were asked to play a serious game, "Hit the Cancer" (RAW HAND, Seoul, Korea), for at least 30 minutes/day, 5 days/week, for 3 weeks. Participants in the Nongame group received usual care. At baseline and follow-up, all participants were assessed with the Beck Depression Inventory (BDI), Beck Anxiety Inventory, Stress Response Inventory (SRI), and 3-Tesla resting-state functional magnetic resonance imaging. Changes in functional connectivity (FC) between the brain regions in the default mode network (DMN) and salience network (SN) were analyzed. Results: After the intervention, BDI and SRI scores in the Game group greatly decreased compared with those in the Nongame group. In addition, compared with the Nongame group, the Game group showed decreased post-intervention FC between the right posterior cingulate cortex (PCC) of the DMN and right insula of the SN. The improvement in BDI and SRI scores correlated with the decrease in FC between the right PCC and right insula. Conclusion: Selective attention training and repetitive stimulation of the insula by serious game play might cause normalization of the FC between the SN and DMN, thus improving depressive mood.
引用
收藏
页码:409 / 417
页数:9
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