Gold-Catalyzed Intramolecular Dearomatization Reactions of Indoles for the Synthesis of Spiroindolenines and Spiroindolines

被引：52

作者：

Wu, Wen-Ting ^{[1
]}

Ding, Lu ^{[2
]}

Zhang, Liming ^{[3
]}

You, Shu-Li ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 LinglingLu, Shanghai 200032, Peoples R China

[2] ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China

[3] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 04期

基金：

国家重点研发计划;

关键词：

NATURAL-PRODUCTS; ENANTIOSELECTIVE CONSTRUCTION; RECENT PROGRESS; CARBENES; CASCADE; CYCLOPROPANATION; ALKYLATION; INDOLINES; LIGANDS; ALKYNES;

D O I：

10.1021/acs.orglett.9b03988

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A gold-catalyzed dearomatization reaction of indole derivatives was realized in the presence of JohnPhosAuCl/AgOMs to afford a series of spiroindolenines in excellent yields (<= 99%). In addition, when the Hantzsch ester was used as the hydrogen transfer reagent, various spiroindolines were obtained in a cascade fashion starting from readily available indole derivatives in modest to good yields (<= 79%). Both reactions feature readily available substrates, mild conditions, and good functional group tolerance.

引用

页码：1233 / 1238

页数：6

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