Association of Genetic Polymorphisms in FOXA1 with the Progression of Genetic Susceptibility to Gastric Cancer

被引：4

作者：

Ding, Guo-wen ^{[1
]}

Gu, Xu-yu ^{[2
]}

Dai, Zhe ^{[1
]}

Pan, Hui-wen ^{[1
]}

Wang, Xiao-yan ^{[3
]}

Zhang, Heng ^{[4
]}

Fan, Yu ^{[1
]}

机构：

[1] Jiangsu Univ, Dept Thorac Surg, Affiliated Peoples Hosp, Zhenjiang 212002, Jiangsu, Peoples R China

[2] Jiangsu Univ, Affiliated Peoples Hosp, Inst Oncol, Zhenjiang 212002, Jiangsu, Peoples R China

[3] First Peoples Hosp Suqian, Dept Gastroenterol, Suqian, Jiangsu, Peoples R China

[4] Southeast Univ, Nanjing Lishui Dist Peoples Hosp, Zhongda Hosp, Dept Gen Surg,Lishui Branch, Nanjing 211200, Peoples R China

来源：

GASTROENTEROLOGY RESEARCH AND PRACTICE | 2020年 / 2020卷

关键词：

FORKHEAD-BOX A1; TRANSCRIPTION FACTOR; GROWTH; CARCINOMA; METASTASIS; EXPRESSION; PROGNOSIS; INFECTION; GENOMICS; PROMOTES;

D O I：

10.1155/2020/3075837

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective. To investigate the relationship between polymorphism of FOXA1 gene rs12894364 and rs7144658 and susceptibility to gastric cancer. Methods. A case-control study was conducted to select 577 cases of primary gastric cancer and 678 cases of normal control. We extracted whole blood genomic DNA and amplified the target gene fragment by PCR. The genotyping and allele was tested through a snapshot method. Results. There was no significant difference in the frequency distribution of genotype between the case group and control group (P>0.05). Stratified analyses showed the SNPs were not correlated with the susceptibility of GC according to different age, gender, cigarette smoking, and alcohol drinking status. Conclusion. There is no significant correlation between the polymorphisms of FOXA1 gene rs12894364 and rs7144658 and the risk of gastric cancer.

引用

页数：8

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