An Efficient Synthesis and Biological Testing of Novel 3-Chloro-4-aryl-1-(4-(phenyldiazenyl)phenyl)azetidin-2-ones

被引：11

作者：

Chopde, Himani N. ^{[1
]}

Pagadala, Ramakanth ^{[1
]}

Meshram, Jyotsna S. ^{[1
]}

Jetti, Venkateshwarlu ^{[1
]}

机构：

[1] Rashtrasant Tukadoji Maharaj Nagpur Univ, Dept Chem, Nagpur 440033, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 06期

关键词：

BETA-LACTAM ANTIBIOTICS; STEREOCONTROLLED SYNTHESIS; AZETIDIN-2-ONES; MILLENNIUM; DESIGN;

D O I：

10.1002/jhet.459

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzylidene-4-(phenyldiazenyl)aniline (Ia-Ij) has been prepared from p-aminoazobenzene with different aromatic aldehydes under microwave irradiation, which on further treatment with chloro acetic acid and POCl3 in the presence of triethyl amine gave the title compounds. The structure of the compounds has been confirmed by spectroscopic techniques (IR and H-1 NMR) and elemental analysis. These azetidinones analogues were screened for their antimicrobial activities against strains of different microorganisms. Some of the compounds displayed the promising antibacterial activities against some bacterial strains.

引用

页码：1361 / 1366

页数：6

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