Delivery of Stem Cell Secretome for Therapeutic Applications

被引：24

作者：

Li, Fenfang ^{[1
]}

Zhang, Jiabin ^{[1
]}

Yi, Ke ^{[1
]}

Wang, Haixia ^{[1
]}

Wei, Hongyan ^{[1
]}

Chan, Hon Fai ^{[2
]}

Tao, Yu ^{[1
]}

Li, Mingqiang ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Lab Biomat & Translat Med, Ctr Nanomed, Affiliated Hosp 3, Guangzhou 510630, Peoples R China

[2] Chinese Univ Hong Kong, Sch Biomed Sci, Inst Tissue Engn & Regenerat Med, Hong Kong 999077, Peoples R China

[3] Guangdong Prov Key Lab Liver Dis, Guangzhou 510630, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 5卷 / 05期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

stem cell; secretome; biomaterial; delivery; therapeutic applications; ACUTE LIVER-FAILURE; EXTRACELLULAR VESICLES; CONDITIONED MEDIUM; MOUSE MODEL; HYDROGEL; EXOSOMES; SCAFFOLDS; PROLIFERATION; REGENERATION; PRINCIPLES;

D O I：

10.1021/acsabm.1c01312

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Intensive studies on stem cell therapy reveal that benefits of stem cells attribute to the paracrine effects. Hence, direct delivery of stem cell secretome to the injured site shows the comparative therapeutic efficacy of living cells while avoiding the potential limitations. However, conventional systemic administration of stem cell secretome often leads to rapid clearance in vivo. Therefore, a variety of different biomaterials are developed for sustained and controllable delivery of stem cell secretome to improve therapeutic efficiency. In this review, we first introduce current approaches for the preparation and characterization of stem cell secretome as well as strategies to improve their therapeutic efficacy and production. The upto-date delivery platforms are also summarized, including nanoparticles, injectable hydrogels, microneedles, and scaffold patches. Meanwhile, we discuss the underlying therapeutic mechanism of stem cell secretome for the treatment of various diseases. In the end, future opportunities and challenges are proposed.

引用

页码：2009 / 2030

页数：22

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