Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

被引：16
|
作者：
Esposito, A [1 ]
Falorni, M [1 ]
Taddei, M [1 ]
机构：
[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 36期
关键词：
pyrrolidines; antivirals; enzyme inhibitors; cyclisation;
D O I：
10.1016/S0040-4039(98)01361-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-I activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6543 / 6546
页数：4
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