Coma With Absent Brainstem Reflexes Resulting From Zolpidem Overdose

被引：53

作者：

Kuzniar, Tomasz J. ^{[2
]}

Balagani, Rajesh ^{[1
]}

Radigan, Kathryn A. ^{[1
]}

Factor, Phillip ^{[3
]}

Mutlu, Goekhan M. ^{[2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

[2] NorthShore Univ HealthSyst, Div Pulm & Crit Care Med, Evanston, IL USA

[3] Columbia Univ, Coll Physicians & Surg, Div Pulm Allergy & Crit Care Med, New York, NY USA

来源：

AMERICAN JOURNAL OF THERAPEUTICS | 2010年 / 17卷 / 05期

关键词：

zolpidem; overdose; suicide; coma; brainstem; glasgow comascale; depression; respiratory failure; SEDATIVE DRUGS; DEATH; INTOXICATION;

D O I：

10.1097/MJT.0b013e318188bdca

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zolpidem is a nonbenzodiazepine hypnotic with a favorable adverse effect profile. There are single reports of respiratory decompensation associated with zolpidem overdose. We report a case of a young woman with depression who developed deep coma with respiratory failure and a loss of brainstem reflexes as a result of zolpidem overdose. Supportive management led to a complete recovery of neurologic function. Acute zolpidem overdose should be considered in the differential diagnosis of coma with absent brainstem reflexes.

引用

页码：E172 / E174

页数：3

共 50 条

[41] Coma resulting from a grade IV anaphylactic reaction to atracurium
Biskup, E.
Qu, C.
Guo, X.
Taegtmeyer, A.
REVUE FRANCAISE D ALLERGOLOGIE, 2015, 55 (02): : 64 - 67
[42] Neurophysiological studies of brainstem functions and reflexes Publications from the Brainstem Society Meeting. Berlin, March 2014
Valls-Sole, Josep
CLINICAL NEUROPHYSIOLOGY, 2015, 126 (10) : 1869 - 1870
[43] Secondary generalized myoclonus resulting from brainstem ischemic lesion
Saaf, S.
Miqdadi, A.
Lhassani, S.
Hakimi, M.
Aasfara, J.
Hazim, A.
MOVEMENT DISORDERS, 2022, 37 : S310 - S311
[44] Myocardial infarction resulting from caffeine overdose in an anorectic woman
Forman, J
Aizer, A
Young, CR
ANNALS OF EMERGENCY MEDICINE, 1997, 29 (01) : 178 - 180
[45] WATERHOUSE-FRIDERICHSEN SYNDROME RESULTING FROM COLCHICINE OVERDOSE
STRINGFELLOW, HF
HOWAT, AJ
TEMPERLEY, JM
PHILLIPS, M
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1993, 86 (11) : 680 - 680
[46] Toxicodynetics of an acute overdose resulting from malicious inhalation of scopolamine
Lepennetier, Olivier
Raphalen, Jean-Herle
Deveaux, Marc
Carton, Sophie
Leger, Sophie
Baud, Frederic J.
Lamhaut, Lionel
Carli, Pierre
TOXICOLOGIE ANALYTIQUE ET CLINIQUE, 2019, 31 (03) : 183 - 188
[47] A human brain network derived from coma-causing brainstem lesions
Fischer, David B.
Boes, Aaron D.
Demertzi, Athena
Evrard, Henry C.
Laureys, Steven
Edlow, Brian L.
Liu, Hesheng
Saper, Clifford B.
Pascual-Leone, Alvaro
Fox, Michael D.
Geerling, Joel C.
NEUROLOGY, 2016, 87 (23) : 2427 - 2434
[48] CANINE CARDIOVASCULAR REFLEXES RESULTING FROM CAPSAICIN STIMULATED GASTRIC RECEPTORS
LONGHURST, JC
ASHTON, JH
CIRCULATION, 1978, 58 (04) : 9 - 9
[49] Coma Following 70% Isopropanol Enema Resulting from Televised Administration
Webb, A. N.
Beuhler, M. C.
CLINICAL TOXICOLOGY, 2009, 47 (07) : 750 - 750
[50] Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication
Topcu, I
Yentur, EA
Kefi, A
Ekici, NZ
Sakarya, M
ANAESTHESIA AND INTENSIVE CARE, 2005, 33 (04) : 518 - 520

← 1 2 3 4 5 →