A new alternative to the Mannich reaction:: Tandem radical addition-cyclization reaction for asymmetric synthesis of γ-butyrolactones and β-amino acids

被引：84

作者：

Miyabe, H ^{[1
]}

Fujii, K ^{[1
]}

Goto, T ^{[1
]}

Naito, T ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol006716g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The radical addition-cyclization reaction of substrates having two different radical accepters such as acrylate and aldoxime ether moieties was studied. This new free radical mediated Mannichtype reaction proceeded smoothly via a tandem C-C bond-forming process. Furthermore, the diastereoselective tandem reaction provides the novel method for asymmetric synthesis of gamma -butyrolactones and beta -amino acid derivatives.

引用

页码：4071 / 4074

页数：4

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