Analysis on time-lagged gene clusters in time series gene expression data

There are a number of previous approaches for identifying time-lagged gene co-regulations. Popularly used cross-correlation method and edge detection method don't consider the direction of regulation of gene pairs. And event method is proposed to deal with some of the above-mentioned limitations however its scoring system to identify promising time-lagged gene pairs is still questionable. This paper further analyses the time-lagged gene clusters mining process and some probably existing deduced direction of co-regulation's contradictory phenomenon in these clusters/bi-clusters. Besides, the time-lagged value is proposed as a possible prevention mechanism.