Inclusion complexation of nimesulide with β-cyclodextrins

被引：13
|
作者：
Vavia, PR [1 ]
Adhage, NA [1 ]
机构：
[1] Univ Mumbai, Dept Chem Technol Autonomous, Div Pharmaceut, Matunga 400019, Mumbai, India
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 04期
关键词：
D O I：
10.1081/DDC-100102206
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nimesulide (NM), a nonsteroidal anti-inflammatory drug (NSAID) has poor aqueous solubility. The present study describes the complexation of NM with beta-cyclodextrin (beta-CD) and its derivative hydroxypropyl beta-cyclodextrin (HP beta-CD). The complexation was studied by phase solubility method, Fourier transformed infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffractometry (XRD). The complexes were prepared by a freeze-drying technique. The in vitro dissolution rate of drug-HP beta-CD complex was faster compared to the drug-beta-CD complex and drug alone.
引用
收藏
页码：543 / 545
页数：3
相关论文
共 50 条
  • [41] Solubility Study of Nimodipine Inclusion Complexation with α- and β-Cyclodextrin and some Substituted Cyclodextrins
    František Kopecký
    Božena Kopecká
    Pavol Kaclík
    Journal of inclusion phenomena and macrocyclic chemistry, 2001, 39 : 215 - 217
  • [42] Solubility study of nimodipine inclusion complexation with α- and β-cyclodextrin and some substituted cyclodextrins
    Kopecky, F
    Kopecká, B
    Kaclík, P
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2001, 39 (3-4) : 215 - 217
  • [43] Determination of the inclusion complex constant between oleuropein and cyclodextrins by complexation theory
    Carlos Eduardo Barão
    Fátima Paiva-Martins
    Gisella Maria Zanin
    Flavio Faria De Moraes
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 78 : 465 - 470
  • [44] Spectrophotometric study of inclusion complexation of aliphatic alcohols by β-cyclodextrins with azobenzene tether
    Liu, Y
    Zhao, YL
    Zhang, HY
    Fan, Z
    Wen, GD
    Ding, F
    JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (26): : 8836 - 8843
  • [45] Comparative study of the inclusion complexation of pizotifen and ketotifen with native and modified cyclodextrins
    Al Omari, Mahmoud M.
    El-Barghouthi, Musa I.
    Zughul, Mohammad B.
    Davies, J. Eric D.
    Badwan, Adnan A.
    JOURNAL OF SOLUTION CHEMISTRY, 2008, 37 (02) : 249 - 264
  • [46] Determination of the inclusion complex constant between oleuropein and cyclodextrins by complexation theory
    Barao, Carlos Eduardo
    Paiva-Martins, Fatima
    Zanin, Gisella Maria
    De Moraes, Flavio Faria
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2014, 78 (1-4) : 465 - 470
  • [47] Comparative Study of the Inclusion Complexation of Pizotifen and Ketotifen with Native and Modified Cyclodextrins
    Mahmoud M. Al Omari
    Musa I. El-Barghouthi
    Mohammad B. Zughul
    J. Eric D. Davies
    Adnan A. Badwan
    Journal of Solution Chemistry, 2008, 37 : 249 - 264
  • [48] Supramolecular inclusion complexation of simvastatin with methylated β-cyclodextrins for promoting osteogenic differentiation
    Terauchi, Masahiko
    Inada, Takasuke
    Tonegawa, Asato
    Tamura, Atsushi
    Yamaguchi, Satoshi
    Harada, Kiyoshi
    Yui, Nobuhiko
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 93 : 1492 - 1498
  • [49] INCLUSION COMPLEXATION BY BIS-CYCLODEXTRINS IN THE PRESENCE OF PHOSPHOLIPID-VESICLES
    SIKORSKI, CT
    PETTER, RC
    WALDECK, DH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 330 - ORGN
  • [50] Inclusion complexation of Itraconazole with β-and 2-hydroxypropyl-β-cyclodextrins in aqueous solutions
    M. I. El-Barghouthi
    N. A. Masoud
    J. K. Al-Kafawein
    A. A. Abdoh
    Russian Journal of Physical Chemistry, 2006, 80 : 1050 - 1055
12345