Synthesis of benzisothiazoles by a three-component reaction using elemental sulfur and ammonium as heteroatom components under transition metal-free conditions

被引：12
|
作者：
Wang, Min [1 ]
Meng, Xia [1 ]
Cai, Changqun [1 ]
Wang, Lingyun [1 ,2 ]
Gong, Hang [1 ]
机构：
[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China
[2] Hunan Inst Technol, Sch Mat & Chem Engn, Hengyang 421002, Peoples R China
来源：
GREEN SYNTHESIS AND CATALYSIS | 2022年 / 3卷 / 02期
关键词：
Synthetic methodology; Three-component reaction; Transition-metal free; Sulfur; Benzisothiazole; REDOX CONDENSATION REACTION; S BOND FORMATION; OXIDATIVE ANNULATION; O-HALONITROBENZENES; EFFICIENT SYNTHESIS; ACCESS; THIAZOLES; 2-NITROCHALCONES; BENZOTHIAZOLES; ISOTHIAZOLES;
D O I：
10.1016/j.gresc.2022.03.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A strategy for the synthesis of benzisothiazoles by a three-component reaction was developed using elemental sulfur and ammonium as heteroatom components under transition metal-free conditions. The reaction is preferably based on pyridine or quinoline ring substrate, and good to excellent yields can be obtained. Notably, this reaction has been applied to the gram-scale synthesis of bioactive molecules.
引用
收藏
页码：168 / 174
页数：7
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