Metal-Free Decarboxylative Three-Component Coupling Reaction for the Synthesis of Propargylamines

被引：76
|
作者：
Park, Kyungho [1 ]
Heo, Yumi [1 ]
Lee, Sunwoo [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 13期
基金：
新加坡国家研究基金会;
关键词：
ONE-POT SYNTHESIS; ALKYNYL CARBOXYLIC-ACIDS; C-H ACTIVATION; PROPIOLIC ACID; ASYMMETRIC-SYNTHESIS; SECONDARY-AMINES; ALDEHYDES; DIARYLALKYNES; COPPER; SALTS;
D O I：
10.1021/ol401358t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free decarboxylative three-component coupling reaction was developed. When alkynyl carboxylic acids, paraformaldehyde, and amines were reacted in CH3CN at 65 degrees C for 3 h, the desired propargylamines were obtained in good yields. This coupling reaction also showed good yield in water solvent. This reaction showed higher selectivity toward alkynyl carboxylic acids than a terminal alkyne.
引用
收藏
页码：3322 / 3325
页数：4
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