A new triterpenoid from the fruits of Gardenia jasminoides var. radicans Makino

被引：19
|
作者：
Qin, Fang-Min [1 ,2 ]
Liu, Bai-Lian [1 ]
Zhang, Ying [1 ]
Zhou, Guang-Xiong [1 ]
机构：
[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China
[2] Ind Microbe Test Ctr, Guangzhou Inst Ind Microbiol, Guangzhou 510663, Guangdong, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 07期
关键词：
iridoid glycoside; Gardenia jasminoides var. radicans; ursane; 28-nortriterpene; Rubiaceae; LEAVES; GLYCOSIDES;
D O I：
10.1080/14786419.2014.980249
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A novel triterpenoid 3 alpha,16 beta,23,24-tetrahydroxy-28-nor-ursane-12,17,19,21-tetraen (1) was isolated from the fruits of Gardenia jasminoides var. radicans Makino. The structure of the new compounds was elucidated on the basis of spectroscopic analysis including MS and NMR data. Compound 1 was in vitro tested for cytostatic activity on human throat cancer (Hep-2) cell line by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide method and showed mild anticancer activity with the IC50 of 31.2 mu M.
引用
收藏
页码：633 / 637
页数：5
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