Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner

被引：0
|
作者：
Zamberlan, D. C. [1 ]
Amaral, G. P. [1 ]
Arantes, L. P. [1 ]
Machado, M. L. [1 ]
Mizdal, C. R. [2 ]
Campos, M. M. A. [2 ]
Soares, F. A. A. [1 ]
机构：
[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Bioquim & Biol Mol, Programa Posgrad Ciencias Biol Bioqim Toxicol, Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin Toxicol, Santa Maria, RS, Brazil
来源：
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2016年 / 49卷 / 09期
关键词：
Caenorhabditis elegans; Natural compounds; Rosemary; daf-2; Stress resistance; Aging; HEAT-SHOCK FACTOR; LIFE-SPAN; OXIDATIVE STRESS; C-ELEGANS; GENETIC-ANALYSIS; MODEL ORGANISMS; SUPEROXIDE; MUTATION; MUTANTS; EXTRACT;
D O I：
10.1590/1414-431X20165235
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the nonparasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress.
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页数：9
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