Spectrophotometric determination of metoclopramide in pharmaceutical preparations

被引：16
|
作者：
Shah, J [1 ]
Jan, MR [1 ]
Khan, MA [1 ]
Amin, S [1 ]
机构：
[1] Univ Peshawar, Dept Chem, NWFP, Peshawar 25120, Pakistan
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2005年 / 60卷 / 07期
关键词：
D O I：
10.1007/s10809-005-0151-5
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple and rapid spectrophotometric method for the determination of metoclopramide is described. The method is based upon simple diazotization reactions with nitrite and aniline as the coupling reagent. The absorbance was measured at 410 nm. The method was optimized for acidity, the amount of reagents required, and the amount of sodium hydroxide. The range of linearity was 0.5-12.0 mu g/mL.. The method was successfully applied to the determination of metoclopramide in pharmaceutical preparations without any interference from common excipients.
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页码：633 / 635
页数：3
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