Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry

被引：21
|
作者：
Patel, Mitul K. [1 ]
Vijayakrishnan, Balakumar [1 ]
Koeppe, Julia R. [1 ]
Chalker, Justin M. [1 ]
Doores, Katie J. [1 ]
Davis, Benjamin G. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 48期
基金：
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
PROTEINS; MOLECULES; DELIVERY; SPECTRA; SUGARS;
D O I：
10.1039/c0cc03420g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.
引用
收藏
页码：9119 / 9121
页数：3
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