Gastrointestinal stromal tumor of the small intestine with penile metastasis: a case report

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the alimentary tract. GISTs most commonly occur in the stomach (60%), jejunum, and/or ileum (30%). To the best of our knowledge, there have been lacking cases reported in the literature about penile metastasis of GIST. Here, we described one case of liver and penile metastases in a patient who had advanced GIST. The patient underwent a partial small intestine resection of the primary tumor with negative margins but no follow-up adjuvant therapies. After 4 years since his enteral tumor resection, multiple liver metastases were found in succession. Then a two-year course of imatinib mesylate (Gleevec) combined with surgical intervention plus percutaneous microwave coagulation therapy (PMCT) was initiated for treatment. He had penile metastasis at 11 years after resection of the primary tumor, and this mass was resected in a short time. This case is worthy to be reported because penile metastasis from GIST is very rare. It might draw more attention to the diagnosis of the genital organ metastases from GISTs in clinical practice despite the shortage of available data so far.