Synthesis and 15N NMR characterization of 4-vinylbenzyl substituted bases of nucleic acids

被引:19
|
作者
Sedlák, M
Simunek, P
Antonietti, M
机构
[1] Univ Pardubice, Fac Chem Technol, Dept Organ Chem, Pardubice 53210, Czech Republic
[2] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany
关键词
D O I
10.1002/jhet.5570400418
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The following substances have been synthesized and characterized as monomers or intermediates for syntheses of new polymers: 1-(4-vinylbenzyl)uracil (1a), 1-(4-vinylbenzyl)thymine (1b), N-4-acetyl-1-(4-vinylbenzyl)cytosine (1c), 1-(4-vinylbenzyl)cytosine (1d), 9-(4-vinylbenzyl)adenine (2a), 2-amino-9-(4-vinylbenzyl)-6-chloro-9H-purine (2b), and 9-(4-vinylbenzyl)-guanine (2c). The alkylation reactions with 4-vinylbenzyl chloride were catalyzed with anhydrous sodium iodide. The substitution at position 9 in substances 2a-c was confirmed by N-15 NMR.
引用
收藏
页码:671 / 675
页数:5
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