Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey

被引：124

作者：

Sattui, Sebastian Eduardo ^{[1
]}

Liew, Jean W. ^{[2
]}

Kennedy, Kevin ^{[3
]}

Sirotich, Emily ^{[4
]}

Putman, Michael ^{[5
]}

Moni, Tarin T. ^{[6
]}

Akpabio, Akpabio ^{[7
]}

Alpizar-Rodriguez, Deshire ^{[8
]}

Berenbaum, Francis ^{[9
]}

Bulina, Inita ^{[10
]}

Conway, Richard ^{[11
]}

Singh, Aman Dev ^{[12
]}

Duff, Eimear ^{[13
]}

Durrant, Karen L. ^{[14
]}

Gheita, Tamer A. ^{[15
]}

Hill, Catherine L. ^{[16
,17
]}

Howard, Richard A. ^{[18
]}

Hoyer, Bimba F. ^{[19
]}

Hsieh, Evelyn ^{[20
,21
]}

El Kibbi, Lina ^{[22
]}

Kilian, Adam ^{[23
]}

Kim, Alfred Hyoungju ^{[24
]}

Liew, David F. L. ^{[25
,26
]}

Lo, Chieh ^{[27
]}

Miller, Bruce ^{[28
]}

Mingolla, Serena ^{[29
]}

Nudel, Michal ^{[30
]}

Palmerlee, Candace A. ^{[31
]}

Singh, Jasvinder A. ^{[32
,33
]}

Singh, Namrata ^{[34
]}

Ugarte-Gil, Manuel Francisco ^{[35
,36
]}

Wallace, John ^{[37
]}

Young, Kristen J. ^{[38
]}

Bhana, Suleman ^{[39
]}

Costello, Wendy ^{[40
]}

Grainger, Rebecca ^{[41
]}

Machado, Pedro M. ^{[42
,43
]}

Robinson, Philip C. ^{[44
,45
]}

Sufka, Paul ^{[46
]}

Wallace, Zachary S. ^{[47
,48
]}

Yazdany, Jinoos ^{[49
]}

Harrison, Carly ^{[50
]}

Larche, Maggie ^{[51
]}

Levine, Mitchell ^{[52
]}

Foster, Gary ^{[53
]}

Thabane, Lehana ^{[52
]}

Rider, Lisa G. ^{[54
]}

Hausmann, Jonathan S. ^{[48
,55
,56
]}

Simard, Julia F. ^{[57
,58
]}

Sparks, Jeffrey A. ^{[48
,59
]}

机构：

[1] Hosp Special Surg, Div Rheumatol, 535 E 70th St, New York, NY 10021 USA

[2] Boston Univ, Sect Rheumatol, Sch Med, Boston, MA USA

[3] McMaster Univ, Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[4] McMaster Univ, Med, Hamilton, ON, Canada

[5] Med Coll Wisconsin, Dept Med, Milwaukee, WI USA

[6] McMaster Univ, Dept Biochem & Biomed Sci, Fac Sci, Hamilton, ON, Canada

[7] Sheffield Teaching Hosp NHS Fdn Trust, Rheumatol, Sheffield, England

[8] Mexican Coll Rheumatol, Res Unit, Mexico City, DF, Mexico

[9] Sorbonne Univ, Rheumatol, Paris, France

[10] Paul Stradins Clin Univ Hosp, Rheumatol Ctr, Dept Internal Dis, Riga, Latvia

[11] St James Hosp, Rheumatol, Dublin, Ireland

[12] GMC, Community Med, Patiala, Punjab, India

[13] St James Hosp, Dept Rheumatol, Dublin, Ireland

[14] Autoinflammatory Alliance, San Francisco, CA USA

[15] Cairo Univ, Fac Med Rheumatol & Clin Immunol, Cairo, Egypt

[16] Queen Elizabeth Hosp, Rheumatol Dept, Adelaide, SA, Australia

[17] Univ Adelaide, Dept Med, Adelaide, SA, Australia

[18] Spondylitis Assoc Amer, Van Nuys, CA USA

[19] Univ Hosp Schleswig, Med Dept 1, Dept Rheumatol & Clin Immunol, Holstein Campus Kiel, Kiel, Schleswig Holst, Germany

[20] Yale Sch Med, Sect Rheumatol Allergy & Immunol, New Haven, CT USA

[21] VA Connecticut Healthcare System, Sect Rheumatol, West Haven Campus, West Haven, CT USA

[22] Specialized Med Ctr Hosp, Rheumatology, Riyadh, Saudi Arabia

[23] St Louis Univ, Dept Internal Med, Div Rheumatol, St Louis, MO USA

[24] Washington Univ, Med Rheumatol, St Louis Sch Med, St Louis, MO USA

[25] Austin Hlth, Rheumatol, Heidelberg, Vic, Australia

[26] Austin Hlth, Clin Pharmacol & Therapeut, Heidelberg, Vic, Australia

[27] I Shou Univ, Coll Med, Yanchau Sheng, Taiwan

[28] Univ Calif San Diego, Med, La Jolla, CA USA

[29] Italian Natl Patient Assoc Rehumatoid & Rare Dis, Rome, Italy

[30] Israeli Assoc RMD Patients Mifrakim Tzeirim, Haifa, Israel

[31] Relapsing Polychondritis Fdn, Int Relapsing Polychondritis Res Network, Walnut Creek, CA USA

[32] Univ Alabama Birmingham, Dept Med, Birmingham, AL USA

[33] Birmingham Vet Affairs Med Ctr, Med Serv, Birmingham, AL USA

[34] Univ Washington, Div Rheumatol, Med, Seattle, WA USA

[35] Univ Cientif Sur, Dept Rheumatol, Lima, Peru

[36] Univ Cientif Sur, Lima, Peru

[37] Autoinflammatory UK, Edinburgh, Midlothian, Scotland

[38] Univ Texas SouthWestern, Div Rheumatol, Sch Med, Dallas, TX USA

[39] Crystal Run Healthcare, Middletown, NY USA

[40] Irish Childrens Arthrit Network iCAN, Tipperary, Ireland

[41] Malaghan Inst Med Res, Dept Med, Wellington, New Zealand

[42] UCL, MRC Ctr Neuromuscular Dis, London, England

[43] UCL, Rheumatol, Ctr Rheumatol, London, England

[44] Univ Queensland, Fac Med, Herston, Qld, Australia

[45] Metro North Hosp & Hlth Serv, Royal Brisbane & Womans Hosp Hlth Serv Dist, Herston, Qld, Australia

[46] Healthpartners, St Paul, MN USA

[47] Massachusetts Gen Hosp, Clin Epidemiol Program & Rheumatol Unit, Div Rheumatol Allergy & Immunol, Boston, MA USA

[48] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[49] Univ Calif San Francisco, Med Rheumatol, San Francisco, CA USA

[50] LupusChat, New York, NY USA

来源：

RMD OPEN | 2021年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

COVID-19; vaccination; autoimmune diseases; INFLUENZA VACCINE; ARTHRITIS; REASONS; SAFETY;

D O I：

10.1136/rmdopen-2021-001814

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine. Methods From 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, beliefs and intent about discontinuing disease-modifying antirheumatic drugs (DMARDs) around the time of vaccination, and patient-reported adverse events after vaccination. Results We analysed 2860 adults with systemic rheumatic diseases who received COVID-19 vaccination (mean age 55.3 years, 86.7% female, 86.3% white). Types of COVID-19 vaccines were Pfizer-BioNTech (53.2%), Oxford/AstraZeneca (22.6%), Moderna (21.3%), Janssen/Johnson & Johnson (1.7%) and others (1.2%). The most common rheumatic disease was rheumatoid arthritis (42.3%), and 81.2% of respondents were on a DMARD. The majority (81.9%) reported communicating with clinicians about vaccination. Most (66.9%) were willing to temporarily discontinue DMARDs to improve vaccine efficacy, although many (44.3%) were concerned about rheumatic disease flares. After vaccination, the most reported patient-reported adverse events were fatigue/somnolence (33.4%), headache (27.7%), muscle/joint pains (22.8%) and fever/chills (19.9%). Rheumatic disease flares that required medication changes occurred in 4.6%. Conclusion Among adults with systemic rheumatic disease who received COVID-19 vaccination, patient-reported adverse events were typical of those reported in the general population. Most patients were willing to temporarily discontinue DMARDs to improve vaccine efficacy. The relatively low frequency of rheumatic disease flare requiring medications was reassuring.

引用

页数：10

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