Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography

被引：23
|
作者：
Sanchez, Benjamin [1 ]
Iyer, Shama R. [2 ]
Li, Jia [1 ]
Kapur, Kush [1 ,3 ]
Xu, Su [4 ]
Rutkove, Seward B. [1 ]
Lovering, Richard M. [2 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA USA
[2] Univ Maryland, Sch Med, Dept Orthopaed, AHB, Room 540,100 Penn St, Baltimore, MD 21201 USA
[3] Boston Childrens Hosp, Boston, MA USA
[4] Univ Maryland, Sch Med, Dept Diagnost Radiol & Nucl Med, Baltimore, MD 21201 USA
来源：
MUSCLE & NERVE | 2017年 / 56卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Duchenne muscular dystrophy; edema; electrical impedance myography; in-vivo injury; DUCHENNE MUSCULAR-DYSTROPHY; SKELETAL-MUSCLE; MAGNETIC-RESONANCE; DIELECTRIC-PROPERTIES; MDX MICE; CONTRACTILE FUNCTION; IN-VIVO; EXERCISE; TWITCH; FIBERS;
D O I：
10.1002/mus.25559
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
IntroductionDystrophic muscle is particularly susceptible to eccentric contraction-induced injury. We tested the hypothesis that electrical impedance myography (EIM) can detect injury induced by maximal-force lengthening contractions. MethodsWe induced injury in the quadriceps of wild-type (WT) and dystrophic (mdx) mice with eccentric contractions using an established model. Resultsmdx quadriceps had significantly greater losses in peak twitch and tetany compared with losses in WT quadriceps. Injured muscle showed a significant increase in EIM characteristic frequency in both WT (1777.7%) and mdx (167 +/- 7.8%) quadriceps. EIM also revealed decreased extracellular resistance for both WT and mdx quadriceps after injury. DiscussionOur results show overall agreement between muscle function and EIM measurements of injured muscle, indicating that EIM is a viable tool to assess injury in dystrophic muscle. Muscle Nerve56: E85-E94, 2017
引用
收藏
页码：E85 / E94
页数：10
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