Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines

被引：7

作者：

Liang, Helong ^{[1
]}

Li, Ganzhong ^{[1
]}

Zhang, Lei ^{[1
]}

Wang, Gefei ^{[1
]}

Song, Mingyu ^{[1
]}

Li, Heng ^{[1
]}

Yuan, Bingxin ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 15期

基金：

中国国家自然科学基金;

关键词：

1,3,5-TRIAZINE; COMPLEX;

D O I：

10.1021/acs.orglett.1c01970

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A scalable synthetic strategy to produce a large variety of unsymmetrical trisubstituted 1,3,5-triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to react with amidine, introducing two substituents to the 1,3,5-triazinone ring with a low production cost and a simple workup procedure. The scalability of this method was demon-strated by translating a small-scale procedure to a multi-kilogram-scale synthesis. Chlorination and a further coupling reaction with various nucleophiles could provide unsymmetrical trisubstituted 1,3,5-triazines bearing diverse functional groups.

引用

页码：5821 / 5825

页数：5

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