The relationship between the daily dose, the plasma concentration of AD-5423 (blonanserin), and its plasma anti-dopamine (D2) and anti-serotonin (5-HT2A) activity, and the plasma serotonin/dopamine (S/D) ratio

被引:1
|
作者
Suzuki, H [1 ]
Morokawa, Y [1 ]
Gen, K [1 ]
Takagi, H [1 ]
Yamaguchi, N [1 ]
Tanaka, C [1 ]
Aoba, A [1 ]
机构
[1] St Marianna Univ, Sch Med, Dept Neuropsychiat, Kawasaki, Kanagawa, Japan
关键词
D O I
10.1097/00004850-200305000-00039
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:187 / 187
页数:1
相关论文
共 50 条
  • [41] Pharmacokinetic Evaluation of Blonanserin Transdermal Patch: Population Analysis and Simulation of Plasma Concentration and Dopamine D2 Receptor Occupancy in Clinical Settings
    Kitamura, Atsushi
    Takagaki, Takeshi
    Nemoto, Daisuke
    Tomita, Yoshiko
    Nishibe, Hironori
    Kakuyama, Hiroyoshi
    JOURNAL OF CLINICAL PHARMACOLOGY, 2021, 61 (08): : 1069 - 1080
  • [42] Pharmacokinetics and dopamine D2 and serotonin 5-HT2A receptor occupancy of paliperidone in healthy subjects:: Two open-label, single-dose studies.
    Karlsson, P
    Dencker, E
    Nyberg, S
    Mannaert, E
    Boom, S
    Talluri, K
    Rossenu, S
    Eriksson, B
    Eerdekens, M
    Farde, L
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 79 (02) : P74 - P74
  • [43] The relationship between risperidone plasma levels and dopamine D2 occupancy:: A positron emission tomographic study
    Remington, G
    Kapur, S
    Zipursky, R
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1998, 18 (01) : 82 - 83
  • [44] Translational Modeling of the Asenapine Plasma Concentration-Dopamine D2 Receptor Occupancy Relationship in Rats and Humans
    Shahid, Mohammed
    Henry, Brian
    Prohn, Marita
    de Greef, Rik
    BIOLOGICAL PSYCHIATRY, 2009, 65 (08) : 208S - 208S
  • [45] PLASMA HOMOVANILLIC-ACID, PLASMA ANTI-D1 AND ANTI-D2 DOPAMINE-RECEPTOR ACTIVITY, AND NEGATIVE SYMPTOMS IN CHRONICALLY MEDICATED SCHIZOPHRENIA
    SUZUKI, E
    KANBA, S
    NIBUYA, M
    KOSHIKAWA, H
    NAKAKI, T
    YAGI, G
    BIOLOGICAL PSYCHIATRY, 1992, 31 (04) : 357 - 364
  • [46] Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors
    Zajdel, Pawel
    Marciniec, Krzysztof
    Maslankiewicz, Andrzej
    Grychowska, Katarzyna
    Satala, Grzegorz
    Duszynska, Beata
    Lenda, Tomasz
    Siwek, Agata
    Nowak, Gabriel
    Partyka, Anna
    Wrobel, Dagmara
    Jastrzebska-Wiesek, Magdalena
    Bojarski, Andrzej J.
    Wesolowska, Anna
    Pawlowski, Maciej
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 60 : 42 - 50
  • [47] Proof of Concept Study for Designed Multiple Ligands Targeting the Dopamine D2, Serotonin 5-HT2A, and Muscarinic M1 Acetylcholine Receptors
    Szabo, Monika
    Lim, Herman D.
    Herenbrink, Carmen Klein
    Christopoulos, Arthur
    Lane, J. Robert
    Capuano, Ben
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (03) : 1550 - 1555
  • [48] Differential effects of regulator of G protein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2 receptor-mediated signaling and adenylyl cyclase activity
    Ghavami, A
    Hunt, RA
    Olsen, MA
    Zhang, J
    Smith, DL
    Kalgaonkar, S
    Rahman, Z
    Young, KH
    CELLULAR SIGNALLING, 2004, 16 (06) : 711 - 721
  • [49] Allelic association analysis of dopamine D2, D3, 5-HT2A and GABAg2 receptors and the serotonin transporter genes with heorin abuse in Chinese subjects.
    Li, T
    Liu, X
    Zhao, J
    Hu, X
    Sham, PC
    Collier, DA
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2000, 96 (04): : 520 - 520
  • [50] Serotonin 5-HT1A, 5-HT2A and dopamine D2 receptors strongly influence prefronto-hippocampal neural networks in alert mice: Contribution to the actions of risperidone
    Gener, Thomas
    Tauste Campo, Adria
    Alemany-Gonzalez, Maria
    Nebot, Pau
    Delgado-Sallent, Cristina
    Chanovas, Jordi
    Victoria Puig, M.
    NEUROPHARMACOLOGY, 2019, 158