Chromatin-modifying proteins in cancer

被引：22
|
作者：
Fog, Cathrine K. [1 ]
Jensen, Klaus T. [1 ]
Lund, Anders H. [1 ]
机构：
[1] Univ Copenhagen, Ctr Epigenet, Biotech Res & Innovat Ctr, DK-1168 Copenhagen, Denmark
来源：
APMIS | 2007年 / 115卷 / 10期
关键词：
chromatin; epigenetics; cancer; DNA methylation; histone code;
D O I：
10.1111/j.1600-0463.2007.apm_776.xml.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chromatin-modifying proteins mold the genome into areas that are accessible for transcriptional activity and areas that are transcriptionally silent. This epigenetic gene regulation allows for different transcriptional programs to be conducted in different cell types at different timepoints-despite the fact that all cells in the organism contain the same genetic information. A large amount of data gathered over the last decades has demonstrated that deregulation of chromatin-modifying proteins is etiologically involved in the development and progression of cancer. Here we discuss how epigenetic alterations influence cancer development and review known cancer-associated alterations in chromatin-modifying proteins.
引用
收藏
页码：1060 / 1089
页数：30
相关论文
共 50 条
  • [31] Small-molecule chromatin-modifying agents: therapeutic applications
    Mai, Antonello
    EPIGENOMICS, 2010, 2 (02) : 307 - 324
  • [32] Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling
    Chevillard-Briet, Martine
    Quaranta, Muriel
    Grezy, Aude
    Mattera, Lise
    Courilleau, Celine
    Philippe, Magali
    Mercier, Pascale
    Corpet, Denis
    Lough, John
    Ueda, Takeshi
    Fukunaga, Rikiro
    Trouche, Didier
    Escaffit, Fabrice
    HUMAN MOLECULAR GENETICS, 2014, 23 (08) : 2120 - 2131
  • [33] Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells
    Ruau, David
    Ensenat-Waser, Roberto
    Dinger, Timo C.
    Vallabhapurapu, Duttu S.
    Rolletschek, Alexandra
    Hacker, Christine
    Hieronymus, Thomas
    Wobus, Anna M.
    Mueller, Albrecht M.
    Zenke, Martin
    STEM CELLS, 2008, 26 (04) : 920 - 926
  • [34] Chromatin-modifying elements for recombinant protein production in mammalian cell systems
    Guo, Xiao
    Wang, Chong
    Wang, Tian-Yun
    CRITICAL REVIEWS IN BIOTECHNOLOGY, 2020, 40 (07) : 1035 - 1043
  • [35] Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes
    Hassan, AH
    Prochasson, P
    Neely, KE
    Galasinski, SC
    Chandy, M
    Carrozza, MJ
    Workman, JL
    CELL, 2002, 111 (03) : 369 - 379
  • [36] The TRPM7 Chanzyme Is Cleaved to Release a Chromatin-Modifying Kinase
    Krapivinsky, Grigory
    Krapivinsky, Luba
    Manasian, Yunona
    Clapham, David E.
    CELL, 2014, 157 (05) : 1061 - 1072
  • [37] Multiple methyl-histone binding domains in chromatin-modifying complexes
    Johnson, I. J.
    Howe, L. J.
    BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2009, 87 (01): : 354 - 354
  • [38] In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents
    Schmittwolf, C
    Kirchhof, N
    Jauch, A
    Dürr, M
    Harder, F
    Zenke, M
    Müller, AM
    EMBO JOURNAL, 2005, 24 (03): : 554 - 566
  • [39] Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines
    Kadonaga, JT
    CELL, 1998, 92 (03) : 307 - 313
  • [40] Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
    Meng L.
    Cell Death Discovery, 9 (1)
12345