Synthesis of 2-Pyridones and Iminoesters via Rh(III)-Catalyzed Oxidative Coupling between Acrylamides and Alkynes

被引：174
|
作者：
Su, Yan [1 ]
Zhao, Miao [1 ]
Han, Keli [1 ]
Song, Guoyong [1 ]
Li, Xingwei [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 23期
关键词：
C-BOND FORMATION; 2+2+2 CYCLOADDITION; CATALYZED SYNTHESIS; H ACTIVATION; O BOND; COUPLING/CYCLIZATION; ISOCYANATES; DERIVATIVES; CLEAVAGE; ALPHA; OMEGA-DIYNES;
D O I：
10.1021/ol102306c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Catalytic oxidative coupling between acrylamides and alkynes was achieved using 0.5 mol % loading of [RhCp*Cl-2](2) with Cu(OAc)(2) as an oxidant. 2-Pyridones, iminoesters, and substituted indoles could be obtained as a result of the electronic and steric effects of the substituents in the acrylamides.
引用
收藏
页码：5462 / 5465
页数：4
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