Electroacupuncture-attenuated ischemic brain injury increases insulin-like growth factor-1 expression in a rat model of focal cerebral ischemia

被引：0

作者：

Gao, Huanmin ^{[1
]}

Wang, Ling ^{[1
]}

Guo, Yunliang ^{[2
]}

机构：

[1] Qingdao Univ, Coll Med, Dept Neurol, Affiliated Hosp 2, Qingdao 266042, Shandong, Peoples R China

[2] Qingdao Univ, Coll Med, Shandong Prov Key Lab Brain Dis Prevent & Treatme, Inst Cerebral Vasc Dis, Qingdao 266003, Shandong, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2010年 / 5卷 / 18期

关键词：

electroacupuncture; cerebral ischemia; focal; insulin-like growth factor-1; brain injury; neural regeneration; TRANSIENT FOREBRAIN ISCHEMIA; HYPOXIA-ISCHEMIA; RELEASE; IGF-1;

D O I：

10.3969/j.issn.1673-5374.2010.18.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acupuncture has recently gained popularity in many countries as an alternative and complementary therapeutic intervention Previous studies have shown that changes in genes, proteins, and their metabolites were measureable during acupuncture for treatment of cerebral ischemia Through the use of in situ hybridization and immunohistochemistry, the present study confirmed that electroacupuncture increased insulin-like growth factor-1 mRNA and protein expression in the corpus striatum following cerebral ischemia, reduced brain edema following middle cerebral artery occlusion reperfusion, and decreased infarct volume Results suggested that electroacupuncture is effective in the relief of cerebral ischemia by increasing endogenous insulin-like growth factor-1 expression

引用

页码：1408 / 1412

页数：5

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