West Nile Virus in Brazil

被引：15

作者：

Costa, Erica Azevedo ^{[1
]}

Giovanetti, Marta ^{[2
,3
]}

Silva Catenacci, Lilian ^{[4
]}

Fonseca, Vagner ^{[3
,5
,6
]}

Aburjaile, Flavia Figueira ^{[3
]}

Chalhoub, Flavia L. L. ^{[2
]}

Xavier, Joilson ^{[3
]}

Campos de Melo Iani, Felipe ^{[7
]}

Cunha e Silva Vieira, Marcelo Adriano da ^{[8
]}

Freitas Henriques, Danielle ^{[9
]}

Medeiros, Daniele Barbosa de Almeida ^{[9
]}

Guedes, Maria Isabel Maldonado Coelho ^{[1
]}

Senra Alvares da Silva Santos, Beatriz ^{[1
]}

Goncalves Silva, Aila Solimar ^{[1
]}

de Pino Albuquerque Maranhao, Renata ^{[10
]}

da Costa Faria, Nieli Rodrigues ^{[2
]}

Farinelli de Siqueira, Renata ^{[11
]}

de Oliveira, Tulio ^{[5
]}

Ribeiro Leite Jardim Cavalcante, Karina ^{[12
]}

Oliveira de Moura, Noely Fabiana ^{[12
]}

Pecego Martins Romano, Alessandro ^{[12
]}

Campelo de Albuquerque, Carlos F. ^{[13
]}

Soares Feitosa, Lauro Cesar ^{[14
]}

Martins Bayeux, Jose Joffre ^{[15
]}

Bertoni Cavalcanti Teixeira, Raffaella ^{[16
]}

Lisboa Lobato, Osmaikon ^{[17
]}

da Costa Silva, Silvokleio ^{[17
]}

Bispo de Filippis, Ana Maria ^{[2
]}

Venancio da Cunha, Rivaldo ^{[18
]}

Lourenco, Jose ^{[19
]}

Alcantara, Luiz Carlos Junior ^{[2
,3
]}

机构：

[1] Univ Fed Minas Gerais, Dept Med Vet Prevent, BR-31270901 Belo Horizonte, MG, Brazil

[2] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Flavivirus, BR-21040360 Rio De Janeiro, Brazil

[3] Univ Fed Minas Gerais, Lab Genet Celular & Mol, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Piaui, Dept Morfofisiol Vet, BR-64049550 Teresina, Brazil

[5] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, ZA-4041 Durban, South Africa

[6] Minist Saude, Coordenacao Geral Labs Saude Publ, Secretaria Vigilancia Saude, CGLAB,SVS,MS, BR-70719040 Brasilia, DF, Brazil

[7] Fundacao Ezequiel Dias, Lab Cent Saude Publ, BR-30510010 Belo Horizonte, MG, Brazil

[8] Fundacao Municipal Saude, Diretoria Vigilancia Saude, BR-64600000 Teresina, Brazil

[9] Minist Saude, Inst Evandro Chagas, Secao Arbovirol & Febres Hemorrag, BR-70058900 Ananindeua, Brazil

[10] Univ Fed Minas Gerais, Escola Vet, Hosp Vet, Setor Clin Equinos, Campus Pampulha, BR-31270901 Belo Horizonte, MG, Brazil

[11] Univ Fed Santa Maria, Dept Large Anim Clin, BR-97105900 Santa Maria, RS, Brazil

[12] Minist Saude, Secretaria Vigilancia Saude, Coordenacao Geral Arboviroses, BR-70058900 Brasilia, DF, Brazil

[13] Org Mundial Saude, Org Pan Amer Saude, BR-40010010 Brasilia, DF, Brazil

[14] Univ Fed Piaui, Dept Clin & Cirurgia Vet, Ctr Ciencias Agr, BR-64049550 Teresina, Brazil

[15] Univ Vale Paraiba, UNIVAP, Urbanova, Fac Ciencias Saude,Med Vet, BR-12245720 Sao Paulo, Brazil

[16] Univ Fed Minas Gerais, Dept Clin & Cirurgia Vet, BR-31270901 Belo Horizonte, MG, Brazil

[17] Univ Fed Piaui, Lab Genet & Conservacao Germoplasma, Campus Prof Cinobelina Elvas, BR-64049550 Bom Jesus, Piaui, Brazil

[18] Fundacao Oswaldo Cruz, Coordenacao Labs Referencia, BR-21040360 Rio De Janeiro, Brazil

[19] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

PATHOGENS | 2021年 / 10卷 / 07期

基金：

欧盟地平线“2020”; 美国国家卫生研究院;

关键词：

West Nile virus; genomic monitoring; molecular detection; Brazil; HORSES; ZIKA;

D O I：

10.3390/pathogens10070896

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: West Nile virus (WNV) was first sequenced in Brazil in 2019, when it was isolated from a horse in the Espirito Santo state. Despite multiple studies reporting serological evidence suggestive of past circulation since 2004, WNV remains a low priority for surveillance and public health, such that much is still unknown about its genomic diversity, evolution, and transmission in the country. Methods: A combination of diagnostic assays, nanopore sequencing, phylogenetic inference, and epidemiological modeling are here used to provide a holistic overview of what is known about WNV in Brazil. Results: We report new genetic evidence of WNV circulation in southern (Minas Gerais, Sao Paulo) and northeastern (Piaui) states isolated from equine red blood cells. A novel, climate-informed theoretical perspective of the potential transmission of WNV across the country highlights the state of Piaui as particularly relevant for WNV epidemiology in Brazil, although it does not reject possible circulation in other states. Conclusion: Our output demonstrates the scarceness of existing data, and that although there is sufficient evidence for the circulation and persistence of the virus, much is still unknown on its local evolution, epidemiology, and activity. We advocate for a shift to active surveillance, to ensure adequate preparedness for future epidemics with spill-over potential to humans.

引用

页数：14

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