A Water-Soluble Polycarbonate With Dimethylamino Pendant Groups Prepared by Enzyme-Catalyzed Ring-Opening Polymerization

被引：29
|
作者：
Zhang, Xiaojin [1 ]
Cai, Mengmeng [1 ]
Zhong, Zhenlin [1 ]
Zhuo, Renxi [1 ]
机构：
[1] Wuhan Univ, Dept Chem, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 08期
基金：
中国国家自然科学基金;
关键词：
aliphatic polycarbonates; degradation; enzyme catalyst; ring-opening polymerization; water-soluble polymers; EFFICIENT SYNTHESIS; CYCLIC CARBONATES; POLY(CARBONATE-ESTER)S; COPOLYMERS; GLYCEROL; BEHAVIOR;
D O I：
10.1002/marc.201100765
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)2 as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.
引用
收藏
页码：693 / 697
页数：5
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